四氧嘧啶对大鼠胰腺多肽（PP）细胞的影响。
Effect of alloxan on rat pancreatic polypeptide (PP) cells.
作者信息
Sundler F, Håkanson R, Lundquist I, Larsson L I
出版信息
Cell Tissue Res. 1977 Mar 16;178(3):307-12. doi: 10.1007/BF00218695.
PMID:321126
Abstract
Injection of alloxan caused an almost total disappearance of insulin cells in the rat pancreas. Planimetric analysis revealed a 50 per cent reduction of the mean islet volume. The number of immunoreactive pancreatic polypeptide (PP) cells per sectioned islet was significantly increased, and the PP cell volume per islet doubled. Assuming an unchanged number of islets, the results indicate an increase in total PP cell mass following alloxan administration.
摘要
注射四氧嘧啶导致大鼠胰腺中胰岛素细胞几乎完全消失。平面测量分析显示平均胰岛体积减少了50%。每个切片胰岛中免疫反应性胰多肽（PP）细胞的数量显著增加，且每个胰岛的PP细胞体积增加了一倍。假设胰岛数量不变，结果表明给予四氧嘧啶后PP细胞总质量增加。
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