胰多肽对低血糖反应受损：糖尿病患者自主神经病变的早期迹象。
Impaired response of pancreatic polypeptide to hypoglycaemia: an early sign of autonomic neuropathy in diabetics.
作者信息
Krarup T, Schwartz T W, Hilsted J, Madsbad S, Verlaege O, Sestoft L
出版信息
Br Med J. 1979 Dec 15;2(6204):1544-6. doi: 10.1136/bmj.2.6204.1544.
Abstract
The pancreatic polypeptide (PP) response to insulin-induced hypoglycaemia was studied in 18 juvenile diabetics and was calculated as the difference between the prestimulatory PP concentration and the maximal concentration measured. The response was severely impaired in patients with autonomic neuropathy (mean +/- SE of mean 22 +/- 12 pmol/l) as compared with patients without neuropathy (252 +/- 51 pmol/l). Patients whose diabetes was of only a few years' duration showed a normal PP response to hypoglycaemia, and the response diminished significantly with increasing duration of diabetes. The decreased PP response to hypoglycaemia was significantly correlated with an increased threshold of the sense of vibration, (rs = 0.86). These results suggest that impaired, secretion of PP may serve as an early sign of autonomic neuropathy in diabetes.
摘要
对18名青少年糖尿病患者的胰岛素诱导低血糖时胰多肽（PP）反应进行了研究，并将其计算为刺激前PP浓度与所测最大浓度之间的差值。与无神经病变的患者（252±51 pmol/l）相比，自主神经病变患者的反应严重受损（平均值±平均值标准误为22±12 pmol/l）。糖尿病病程仅数年的患者对低血糖的PP反应正常，且随着糖尿病病程的延长，反应显著减弱。PP对低血糖反应的降低与振动觉阈值升高显著相关（rs = 0.86）。这些结果表明，PP分泌受损可能是糖尿病自主神经病变的早期征象。
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