Sundler F, Håkanson R, Hammer R A, Alumets J, Carraway R, Leeman S E, Zimmerman E A
Cell Tissue Res. 1977 Mar 16;178(3):313-21. doi: 10.1007/BF00218696.
Endocrine cells displaying neurotensin immunoreactivity are found scattered in the jejuno-ileum of all mammals studied, including man. They are rather scarce in rat, guinea pig, rabbit and pig and fairly numerous in cat, dog and man. In most mammals the neurotensin cells predominate on the villi. Only in the dog are they more numerous in the crypts. In the chicken, neurotensin cells occur all along the intestinal tract. They are particularly numerous in the zone that joins the gizzard with the duodenum. The ontogeny of the neurotensin cells in the gut was studied in rats and chickens. In the rat, the cells are first observed in the jejuno-ileum immediately before birth. The adult frequency is reached 4-5 days later. In the chicken, neurotensin cells first appear in the colon in the 18 day old embryo and in the small intestine two days later (i.e. one or two days before hatching). A few days after hatching, the gut has achieved the adult number of neurotensin cells per unit area.
在包括人类在内的所有已研究哺乳动物的空肠回肠中，均可发现显示神经降压素免疫反应性的内分泌细胞。它们在大鼠、豚鼠、兔子和猪体内相当稀少，而在猫、狗和人类体内数量较多。在大多数哺乳动物中，神经降压素细胞在绒毛上占主导地位。只有在狗的体内，它们在隐窝中的数量更多。在鸡体内，神经降压素细胞沿肠道全程分布。它们在连接砂囊和十二指肠的区域特别多。对大鼠和鸡肠道中神经降压素细胞的个体发生进行了研究。在大鼠中，这些细胞在出生前立即在空肠回肠中首次被观察到。4-5天后达到成年频率。在鸡中，神经降压素细胞在18日龄胚胎的结肠中首次出现，两天后（即孵化前一或两天）在小肠中出现。孵化几天后，肠道每单位面积的神经降压素细胞数量已达到成年水平。
