Yu Lishan, Zhang Qiuchen, Bernstam Elmer V, Jiang Xiaoqian
School of Biomedical Informatics, UTHealth, United States; Department of Mathematical Sciences, Tsinghua University, China.
School of Biomedical Informatics, UTHealth, United States; Department of Computer Science, Emory University, United States.
J Biomed Inform. 2020 Apr;104:103394. doi: 10.1016/j.jbi.2020.103394. Epub 2020 Feb 26.
Serial laboratory testing is common, especially in Intensive Care Units (ICU). Such repeated testing is expensive and may even harm patients. However, identifying specific tests that can be omitted is challenging. The search space of different lab tests is large and the optimal reduction is hard to determine without modeling the time trajectory of decisions, which is a nontrivial optimization problem. In this paper, we propose a novel deep-learning method with a very concise architecture to jointly predict future lab test events to be omitted and the values of the omitted events based on observed testing values. Using our method, we were able to omit 15% of lab tests with <5% prediction accuracy loss. Although the application is specific to repeated lab tests, our proposed framework is highly generalizable and can be used to tackle a family of similar business decision making problems.
连续实验室检测很常见,尤其是在重症监护病房(ICU)。这种重复检测成本高昂,甚至可能对患者造成伤害。然而,确定哪些特定检测可以省略具有挑战性。不同实验室检测的搜索空间很大,如果不建立决策的时间轨迹模型,就很难确定最优的检测减少方案,而这是一个复杂的优化问题。在本文中,我们提出了一种架构非常简洁的新型深度学习方法,基于观察到的检测值联合预测未来要省略的实验室检测事件以及省略事件的值。使用我们的方法,我们能够省略15%的实验室检测,预测准确率损失<5%。尽管该应用特定于重复实验室检测,但我们提出的框架具有高度的通用性,可用于解决一系列类似的商业决策问题。