OBJECTIVE

The purpose of this study is to characterize functional connectivity changes in mild cognitive impaired Alzheimer's disease (MCI-AD) under resting and cognitive task conditions.

METHOD

EEG signals were recorded under resting states (Eyes closed (EC) and Eyes open (EO)) and cognitive states (Mental Arithmetic Eyes closed (MAEC) and Mental Arithmetic Eyes open (MAEO)) conditions. Functional connectivity metrics were calculated using weighted phase lag index (WPLI). Topological features of the functional connectivity network were analyzed through minimum spanning tree (MST) algorithm. Betweenness centrality was estimated in five different regions of the brain to study hub importance.

RESULTS

An increase in values of eccentricity and diameter were observed in patient group in five frequency bands of delta, theta, alpha1, alpha 2 and beta bands under resting and cognitive states. A reduction in leaf fraction was observed in alpha 1 band of EO condition. The results indicated a reduction in functional integration in the brain network of MCI-AD patients. Analysis of MST parameters revealed a higher disintegrated network for the alpha band under EO protocol. The study of hub status in the network displayed an elevated hub status in the central region for the patient group under cognitive task. The study also observed increased integration in gamma band in MCI - AD subjects than healthy controls under cognitive load.

CONCLUSION

Disintegration of functional network in alpha band under eyes open protocol and elevated hub strength in central region during cognitive task could be distinguishing features that could aid early detection of AD.