Department of Physiology and Biophysics, Dalhousie University, 5850 College Street, Room 3E1, Halifax, Nova Scotia, B3H 4R2, Canada,
Department of Pathology, Dalhousie University, 5850 College Street, Room 3E1, Halifax, Nova Scotia, B3H 4R2, Canada.
Front Biosci (Landmark Ed). 2020 Mar 1;25(6):1110-1119. doi: 10.2741/4848.
Because of their highly reactive nature and potentially toxic characteristic, reactive oxygen species (ROS) have had a bad reputation for years. However, under certain conditions, ROS generation has shown positive outcomes. It is ROS imbalance that causes toxic effects. ROS play an important role in physiological processes such as cell signaling, senescence, inflammation, and the immune response to infection. An increasing number of studies highlight the importance of ROS for the inflammatory response, whether sterile or due to infection or cancer. The purpose of this paper is to present evidence of the essential role of ROS in the inflammatory response.
由于其高度反应性和潜在的毒性特征，活性氧（ROS）多年来一直名声不佳。然而，在某些条件下，ROS 的产生显示出了积极的结果。ROS 产生毒性作用是由于 ROS 失衡。ROS 在细胞信号转导、衰老、炎症和对感染的免疫反应等生理过程中发挥着重要作用。越来越多的研究强调了 ROS 对炎症反应的重要性，无论是无菌性的还是由于感染或癌症引起的炎症反应。本文的目的是提出 ROS 在炎症反应中起重要作用的证据。
