深部脑刺激治疗原发性震颤：靶点、技术及临床疗效的全面综述。
Deep brain stimulation in essential tremor: targets, technology, and a comprehensive review of clinical outcomes.
机构信息
Fixel Institute for Neurological Diseases, Department of Neurology, University of Florida, Gainesville, FL, USA.
Department of Radiology, Mayo Clinic, Jacksonville, FL, USA.
出版信息
Expert Rev Neurother. 2020 Apr;20(4):319-331. doi: 10.1080/14737175.2020.1737017. Epub 2020 Mar 2.
Abstract
: Essential tremor (ET) is a common movement disorder with an estimated prevalence of 0.9% worldwide. Deep brain stimulation (DBS) is an established therapy for medication refractory and debilitating tremor. With the arrival of next generation technology, the implementation and delivery of DBS has been rapidly evolving. This review will highlight the current applications and constraints for DBS in ET.: The mechanism of action, targets for neuromodulation, next generation guidance techniques, symptom-specific applications, and long-term efficacy will be reviewed.: The posterior subthalamic area and zona incerta are alternative targets to thalamic DBS in ET. However, they may be associated with additional stimulation-induced side effects. Novel stimulation paradigms and segmented electrodes provide innovative approaches to DBS programming and stimulation-induced side effects.
摘要
特发性震颤（ET）是一种常见的运动障碍，全球估计患病率为 0.9%。深部脑刺激（DBS）是一种针对药物难治性和致残性震颤的成熟治疗方法。随着下一代技术的出现，DBS 的实施和交付正在迅速发展。本综述将重点介绍 DBS 在 ET 中的当前应用和限制。作用机制、神经调节靶点、下一代指导技术、症状特异性应用和长期疗效将得到回顾。在 ET 中，丘脑 DBS 的替代靶点是后丘脑下核和未定带，但它们可能与额外的刺激诱导的副作用相关。新型刺激模式和分段电极为 DBS 编程和刺激诱导的副作用提供了创新方法。
相似文献
1
Deep brain stimulation in essential tremor: targets, technology, and a comprehensive review of clinical outcomes.深部脑刺激治疗原发性震颤：靶点、技术及临床疗效的全面综述。
Expert Rev Neurother. 2020 Apr;20(4):319-331. doi: 10.1080/14737175.2020.1737017. Epub 2020 Mar 2.
2
Deep Brain Stimulation for Essential Tremor: A Comparison of Targets.深部脑刺激治疗特发性震颤：靶点比较
World Neurosurg. 2018 Feb;110:e580-e584. doi: 10.1016/j.wneu.2017.11.064. Epub 2017 Nov 28.
3
Deep brain stimulation of the subthalamic nucleus versus the zona incerta in the treatment of essential tremor.丘脑底核与未定带深部脑刺激治疗原发性震颤。
Acta Neurochir (Wien). 2011 Dec;153(12):2329-35. doi: 10.1007/s00701-011-1157-4. Epub 2011 Sep 10.
4
Probabilistic mapping of deep brain stimulation effects in essential tremor.原发性震颤中脑深部电刺激效果的概率性映射
Neuroimage Clin. 2016 Nov 17;13:164-173. doi: 10.1016/j.nicl.2016.11.019. eCollection 2017.
5
Determining an efficient deep brain stimulation target in essential tremor - Cohort study and review of the literature.确定特发性震颤中的有效深部脑刺激靶点 - 队列研究和文献复习。
Parkinsonism Relat Disord. 2021 Aug;89:54-62. doi: 10.1016/j.parkreldis.2021.06.019. Epub 2021 Jun 29.
6
An Unusual Case of Essential Tremor Deep Brain Stimulation: Where is the Lead?一例罕见的特发性震颤脑深部电刺激病例：电极位置在哪里？
Tremor Other Hyperkinet Mov (N Y). 2019 Mar 7;9:617. doi: 10.7916/d8-xj6w-cm53. eCollection 2019.
7
Early Experience With New Generation Deep Brain Stimulation Leads in Parkinson's Disease and Essential Tremor Patients.新一代脑深部刺激治疗帕金森病和特发性震颤患者的早期经验。
Neuromodulation. 2020 Jun;23(4):537-542. doi: 10.1111/ner.13034. Epub 2019 Aug 21.
8
Evolving Concepts in Posterior Subthalamic Area Deep Brain Stimulation for Treatment of Tremor: Surgical Neuroanatomy and Practical Considerations.丘脑底后区深部脑刺激治疗震颤的概念演变：手术神经解剖学与实际考量
Stereotact Funct Neurosurg. 2016;94(5):283-297. doi: 10.1159/000449007. Epub 2016 Oct 12.
9
Safety and efficacy of dual-lead thalamic deep brain stimulation for patients with treatment-refractory multiple sclerosis tremor: a single-centre, randomised, single-blind, pilot trial.双侧丘脑深部脑刺激治疗难治性多发性硬化震颤的安全性和有效性：单中心、随机、单盲、初步试验。
Lancet Neurol. 2017 Sep;16(9):691-700. doi: 10.1016/S1474-4422(17)30166-7. Epub 2017 Jun 20.
10
Square biphasic pulse deep brain stimulation for essential tremor: The BiP tremor study.立体双相脉冲深部脑刺激治疗原发性震颤：BiP 震颤研究。
Parkinsonism Relat Disord. 2018 Jan;46:41-46. doi: 10.1016/j.parkreldis.2017.10.015. Epub 2017 Oct 20.
引用本文的文献
1
Dentato-rubro-thalamic tract tractography: Constrained spherical deconvolution versus diffusion tensor imaging for essential tremor deep brain stimulation targeting.齿状核-红核-丘脑束纤维束成像：在原发性震颤脑深部电刺激靶点定位中，约束球形反卷积与扩散张量成像的比较
Surg Neurol Int. 2025 May 30;16:211. doi: 10.25259/SNI_924_2024. eCollection 2025.
2
Safety and efficacy of bilateral staged focused ultrasound thalamotomy in refractory essential tremor.双侧分期聚焦超声丘脑切开术治疗难治性特发性震颤的安全性和有效性
Brain Commun. 2025 May 2;7(3):fcaf168. doi: 10.1093/braincomms/fcaf168. eCollection 2025.
3
Cerebellar Oscillatory Patterns in Essential Tremor: Modulatory Effects of VIM-DBS.原发性震颤的小脑振荡模式：丘脑腹中间核深部脑刺激的调节作用
Cerebellum. 2025 Feb 1;24(2):40. doi: 10.1007/s12311-025-01787-1.
4
The research focus and frontiers in surgical treatment of essential tremor.特发性震颤外科治疗的研究重点与前沿
Front Neurol. 2024 Dec 11;15:1499652. doi: 10.3389/fneur.2024.1499652. eCollection 2024.
5
Applied Motor Noise Affects Specific Learning Mechanisms during Short-Term Adaptation to Novel Movement Dynamics.应用运动噪声在短期适应新运动动力学过程中影响特定学习机制。
eNeuro. 2025 Jan 16;12(1). doi: 10.1523/ENEURO.0100-24.2024. Print 2025 Jan.
6
Efficacy and safety of stereotactic radiosurgery with gamma knife machine in patients with essential tremor: a systematic review and single-arm meta-analysis.伽玛刀立体定向放射手术治疗特发性震颤患者的疗效和安全性：系统评价和单臂荟萃分析。
Neurosurg Rev. 2024 Nov 20;47(1):862. doi: 10.1007/s10143-024-03094-5.
7
Computational Neurosurgery in Deep Brain Stimulation.计算神经外科在脑深部刺激中的应用。
Adv Exp Med Biol. 2024;1462:435-451. doi: 10.1007/978-3-031-64892-2_26.
8
The future of transcranial ultrasound as a precision brain interface.经颅超声作为一种精准脑接口的未来。
PLoS Biol. 2024 Oct 29;22(10):e3002884. doi: 10.1371/journal.pbio.3002884. eCollection 2024 Oct.
9
A roadmap towards standardized neuroimaging approaches for human thalamic nuclei.通向人类丘脑核标准化神经影像学方法的路线图。
Nat Rev Neurosci. 2024 Dec;25(12):792-808. doi: 10.1038/s41583-024-00867-1. Epub 2024 Oct 17.
10
Research hotspots and frontiers of essential tremor from 2013 to 2023: a visualization analysis based on CiteSpace.2013年至2023年特发性震颤的研究热点与前沿：基于CiteSpace的可视化分析
Front Aging Neurosci. 2024 Jul 23;16:1380851. doi: 10.3389/fnagi.2024.1380851. eCollection 2024.
本文引用的文献
1
Longitudinal follow-up with VIM thalamic deep brain stimulation for dystonic or essential tremor.采用 VIM 丘脑深部电刺激进行痉挛性或特发性震颤的纵向随访。
Neurology. 2020 Mar 10;94(10):e1073-e1084. doi: 10.1212/WNL.0000000000008875. Epub 2020 Feb 11.
2
The Functional Role of Thalamocortical Coupling in the Human Motor Network.丘脑皮质耦合在人类运动网络中的功能作用。
J Neurosci. 2019 Oct 9;39(41):8124-8134. doi: 10.1523/JNEUROSCI.1153-19.2019. Epub 2019 Aug 30.
3
Early Experience With New Generation Deep Brain Stimulation Leads in Parkinson's Disease and Essential Tremor Patients.新一代脑深部刺激治疗帕金森病和特发性震颤患者的早期经验。
Neuromodulation. 2020 Jun;23(4):537-542. doi: 10.1111/ner.13034. Epub 2019 Aug 21.
4
Mapping stimulation-induced beneficial and adverse effects in the subthalamic area of essential tremor patients.绘制震颤患者丘脑底核区刺激诱导的有益和不良反应图。
Parkinsonism Relat Disord. 2019 Jul;64:150-155. doi: 10.1016/j.parkreldis.2019.03.028. Epub 2019 Apr 3.
5
Gait worsening and the microlesion effect following deep brain stimulation for essential tremor.深部脑刺激治疗原发性震颤后步态恶化和微损伤效应。
J Neurol Neurosurg Psychiatry. 2019 Aug;90(8):913-919. doi: 10.1136/jnnp-2018-319723. Epub 2019 Mar 7.
6
The impact of modern-day neuroimaging on the field of deep brain stimulation.现代神经影像学对深部脑刺激领域的影响。
Curr Opin Neurol. 2019 Aug;32(4):511-520. doi: 10.1097/WCO.0000000000000679.
7
Unilateral Thalamic Deep Brain Stimulation Versus Focused Ultrasound Thalamotomy for Essential Tremor.单侧丘脑深部电刺激与聚焦超声丘脑切开术治疗原发性震颤。
World Neurosurg. 2019 Jun;126:e144-e152. doi: 10.1016/j.wneu.2019.01.281. Epub 2019 Feb 19.
8
Long-term efficacy of deep brain stimulation for essential tremor: An observer-blinded study.深部脑刺激治疗特发性震颤的长期疗效：一项盲法观察者研究。
Neurology. 2019 Mar 19;92(12):e1378-e1386. doi: 10.1212/WNL.0000000000007134. Epub 2019 Feb 20.
9
Alternating Thalamic Deep Brain Stimulation for Essential Tremor: A Trial to Reduce Habituation.交替丘脑深部脑刺激治疗特发性震颤：一项减少适应性的试验。
Mov Disord Clin Pract. 2018 Nov 9;5(6):620-626. doi: 10.1002/mdc3.12685. eCollection 2018 Nov-Dec.
10
Comparing deep brain stimulation in the ventral intermediate nucleus versus the posterior subthalamic area in essential tremor patients.原发性震颤患者腹侧中间核与丘脑底后区深部脑刺激的比较。
Surg Neurol Int. 2018 Dec 4;9:244. doi: 10.4103/sni.sni_234_18. eCollection 2018.
Zotero 插件