Fixel Institute for Neurological Diseases, Department of Neurology, University of Florida, Gainesville, FL, USA.
Department of Radiology, Mayo Clinic, Jacksonville, FL, USA.
Expert Rev Neurother. 2020 Apr;20(4):319-331. doi: 10.1080/14737175.2020.1737017. Epub 2020 Mar 2.
: Essential tremor (ET) is a common movement disorder with an estimated prevalence of 0.9% worldwide. Deep brain stimulation (DBS) is an established therapy for medication refractory and debilitating tremor. With the arrival of next generation technology, the implementation and delivery of DBS has been rapidly evolving. This review will highlight the current applications and constraints for DBS in ET.: The mechanism of action, targets for neuromodulation, next generation guidance techniques, symptom-specific applications, and long-term efficacy will be reviewed.: The posterior subthalamic area and zona incerta are alternative targets to thalamic DBS in ET. However, they may be associated with additional stimulation-induced side effects. Novel stimulation paradigms and segmented electrodes provide innovative approaches to DBS programming and stimulation-induced side effects.
特发性震颤（ET）是一种常见的运动障碍，全球估计患病率为 0.9%。深部脑刺激（DBS）是一种针对药物难治性和致残性震颤的成熟治疗方法。随着下一代技术的出现，DBS 的实施和交付正在迅速发展。本综述将重点介绍 DBS 在 ET 中的当前应用和限制。作用机制、神经调节靶点、下一代指导技术、症状特异性应用和长期疗效将得到回顾。在 ET 中，丘脑 DBS 的替代靶点是后丘脑下核和未定带，但它们可能与额外的刺激诱导的副作用相关。新型刺激模式和分段电极为 DBS 编程和刺激诱导的副作用提供了创新方法。
