Division of Dermatology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
J Dermatolog Treat. 2022 Feb;33(1):23-40. doi: 10.1080/09546634.2020.1737635. Epub 2020 Mar 11.
The treatment of recalcitrant nongenital cutaneous warts has always been challenging for dermatologists as they often recur and relapse. Multiple treatment options have been investigated to improve the outcome. This review provides an overview of the current treatment modalities and summarizes the efficacy and side effects of each treatment option for recalcitrant nongenital cutaneous warts.
A PubMed search was performed through July 2019 to include all English language reports investigating the treatment for recalcitrant nongenital cutaneous warts, regardless of design.
A total of 144 studies were included in this review. The treatment options for recalcitrant nongenital cutaneous warts can be divided into three groups: destructive treatment, immunotherapy, and cytotoxic agents. Although both destructive therapies and cytotoxic agents demonstrated high complete response rates, immunotherapy, which is a minimally invasive method, was superior in terms of the clearance of distant warts. Intralesional mumps-measles-rubella injections and purified protein derivatives currently demonstrate high efficacy with well-established clinical evidence.
Many upcoming treatment modalities, especially immunotherapy, are promising. However, more comparative studies are required to verify the efficacy and safety profile.
治疗顽固的非生殖器皮肤疣一直是皮肤科医生面临的挑战，因为它们经常复发和再次出现。已经研究了多种治疗选择来改善治疗效果。本文综述了目前的治疗方法，并总结了每种治疗选择治疗顽固非生殖器皮肤疣的疗效和副作用。
通过 2019 年 7 月在 PubMed 上进行了搜索，包括所有调查顽固非生殖器皮肤疣治疗的英文报告，无论设计如何。
共有 144 项研究纳入了本综述。治疗顽固非生殖器皮肤疣的选择可分为三组：破坏性治疗、免疫疗法和细胞毒性药物。虽然两种破坏性疗法和细胞毒性药物均显示出较高的完全缓解率，但免疫疗法作为一种微创方法，在清除远处疣方面具有优势。皮内腮腺炎-麻疹-风疹疫苗和纯化蛋白衍生物目前具有较高的疗效，并具有良好的临床证据。
许多新的治疗方法，特别是免疫疗法，很有前途。然而，需要更多的比较研究来验证疗效和安全性。
