Brosius C L, Newburger J W, Burns J C, Hojnowski-Diaz P, Zierler S, Leung D Y
Department of Pediatrics, Harvard Medical School, Boston, MA.
Pediatr Infect Dis J. 1988 Dec;7(12):863-6.
Atopic dermatitis is associated with immunoregulatory abnormalities similar to those observed in acute Kawasaki disease. We investigated whether the prevalence of atopic dermatitis is increased among children who acquire Kawasaki disease. In a case-control telephone survey 83 Kawasaki disease patients and 83 children with innocent heart murmurs were matched for age and time between clinic visit and interview. The interviewer was blinded to the hypothesis of the study. Nine (11%) Kawasaki disease patients but only one (1%) unaffected child had atopic dermatitis; the incidence of atopic dermatitis among children with Kawasaki disease was 9 times greater than that of controls (95% confidence limits, 1.6 to 49.4). Serum immunoglobulin E concentrations were significantly higher (P = 0.02, Mann-Whitney) in 44 unselected Kawasaki disease patients (median, 22; range, less than or equal to 4 to 900 IU/ml) studied 6 to 12 months after onset than in 27 children of similar age (median, less than or equal to 4; range, less than or equal to 4 to 164 IU/ml). We observed that there is a strong association between atopic dermatitis and Kawasaki disease.
特应性皮炎与急性川崎病中观察到的免疫调节异常有关。我们调查了患川崎病的儿童中特应性皮炎的患病率是否增加。在一项病例对照电话调查中，83名川崎病患者和83名有 innocent heart murmurs（此处可能有误，可结合上下文修正为无害心脏杂音之类准确表述）的儿童按年龄以及就诊与访谈之间的时间进行匹配。访谈者对该研究的假设不知情。9名（11%）川崎病患者患有特应性皮炎，而未患病儿童中只有1名（1%）患有特应性皮炎；川崎病患儿中特应性皮炎的发病率比对照组高9倍（95%置信区间，1.6至49.4）。在发病6至12个月后对44名未经挑选的川崎病患者（中位数为22；范围，小于或等于4至900 IU/ml）进行研究，其血清免疫球蛋白E浓度显著高于27名年龄相仿儿童（中位数，小于或等于4；范围，小于或等于4至164 IU/ml）（P = 0.02，曼 - 惠特尼检验）。我们观察到特应性皮炎与川崎病之间存在密切关联。
