Xu Yang, Gao Chao, He Jinwei, Gu Wenqin, Yi Chuntao, Chen Bihua, Wang Qingqing, Tang Feng, Xu Juliang, Yue Hua, Zhang Zhenlin
Shanghai Clinical Research Center of Bone Disease, Department of Osteoporosis and Bone Diseases, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
Fenglin Community Health Service Center, Shanghai, China.
Front Cell Dev Biol. 2020 Feb 7;8:57. doi: 10.3389/fcell.2020.00057. eCollection 2020.
Sclerostin is an important regulator of bone mass involving Wnt/β-catenin signaling pathway. We aimed to obtain the profile of serum sclerostin level and explore its associations with bone metabolism markers and sex hormones in healthy community-dwelling Chinese elderly individuals and adolescents. A cross-sectional study was performed in three communities in Shanghai. In all, 861 participants, including 574 healthy elderly individuals, and 287 healthy adolescents, were recruited. The levels of serum sclerostin, procollagen type 1 N-terminal propeptide (P1NP), β-CrossLaps of type I collagen containing cross-linked C-telopeptide (β-CTX), parathyroid hormone (PTH), 25-hydroxyvitamin D [25(OH)D], estradiol (E), testosterone (T), and sex hormone-binding globulin (SHBG) were measured in blood samples from all participants. Median sclerostin level was higher in males than in females and in elderly individuals than in adolescents (elderly males: 54.89 pmol/L, elderly females: 39.95 pmol/L, adolescent males: 36.58 pmol/L, adolescent females: 27.06 pmol/L; both < 0.05). In elderly individuals, serum sclerostin was positively correlated with age (β = 0.176, < 0.001) and T (β = 0.248, = 0.001), but negatively associated to P1NP (β = -0.140, = 0.001). In adolescents, circulating sclerostin was significantly and positively associated with P1NP (β = 0.192, = 0.003). The directions of the association between sclerostin and P1NP were opposite in Chinese elderly individuals and adolescents, which may reflect that sclerostin plays distinct roles in different functional states of the skeleton. Our findings revealed the rough profile of circulating sclerostin level in general healthy Chinese population and its associations with bone metabolism markers and sex hormones, which may provide a clue to further elucidate the cross action of sclerostin in bone metabolism and sexual development.
硬化素是涉及Wnt/β-连环蛋白信号通路的骨量重要调节因子。我们旨在获取健康社区居住的中国老年人和青少年血清硬化素水平概况，并探讨其与骨代谢标志物及性激素的关联。在上海的三个社区开展了一项横断面研究。共招募了861名参与者，包括574名健康老年人和287名健康青少年。检测了所有参与者血样中血清硬化素、1型前胶原N端前肽（P1NP）、含交联C末端肽的I型胶原β-交联C末端肽（β-CTX）、甲状旁腺激素（PTH）、25-羟基维生素D [25(OH)D]、雌二醇（E）、睾酮（T）和性激素结合球蛋白（SHBG）的水平。男性的血清硬化素水平中位数高于女性，老年人高于青少年（老年男性：54.89 pmol/L，老年女性：39.95 pmol/L，青少年男性：36.58 pmol/L，青少年女性：27.06 pmol/L；均P<0.05）。在老年人中，血清硬化素与年龄呈正相关（β = 0.176，P<0.001）及T呈正相关（β = 0.248，P = 0.001），但与P1NP呈负相关（β = -0.140，P = 0.001）。在青少年中，循环硬化素与P1NP显著正相关（β = 0.192，P = 0.003）。硬化素与P1NP之间的关联方向在中国老年人和青少年中相反，这可能反映出硬化素在骨骼不同功能状态中发挥着不同作用。我们的研究结果揭示了一般健康中国人群循环硬化素水平概况及其与骨代谢标志物和性激素的关联，这可能为进一步阐明硬化素在骨代谢和性发育中的交叉作用提供线索。
