Wang Zhao-Ni, Su Ruo-Nan, Yang Bi-Yuan, Yang Ke-Xin, Yang Li-Fen, Yan Yan, Chen Zhuang-Gui
Department of Pediatrics, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Guangzhou Institute of Respiratory Diseases, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Front Cell Dev Biol. 2020 Feb 11;8:59. doi: 10.3389/fcell.2020.00059. eCollection 2020.
Cellular senescence is a complicated process featured by irreversible cell cycle arrest and senescence-associated secreted phenotype (SASP), resulting in accumulation of senescent cells, and low-grade inflammation. Cellular senescence not only occurs during the natural aging of normal cells, but also can be accelerated by various pathological factors. Cumulative studies have shown the role of cellular senescence in the pathogenesis of chronic lung diseases including chronic obstructive pulmonary diseases (COPD) and idiopathic pulmonary fibrosis (IPF) by promoting airway inflammation and airway remodeling. Recently, great interest has been raised in the involvement of cellular senescence in asthma. Limited but valuable data has indicated accelerating cellular senescence in asthma. This review will compile current findings regarding the underlying relationship between cellular senescence and asthma, mainly through discussing the potential mechanisms of cellular senescence in asthma, the impact of senescent cells on the pathobiology of asthma, and the efficiency and feasibility of using anti-aging therapies in asthmatic patients.
细胞衰老 是一个复杂的过程，其特征为不可逆的细胞周期停滞和衰老相关分泌表型（SASP），导致衰老细胞积累和低度炎症。细胞衰老不仅发生在正常细胞的自然老化过程中，还可被各种病理因素加速。累积研究表明，细胞衰老通过促进气道炎症和气道重塑，在包括慢性阻塞性肺疾病（COPD）和特发性肺纤维化（IPF）在内的慢性肺部疾病发病机制中发挥作用。最近，细胞衰老与哮喘的关系引起了极大关注。有限但有价值的数据表明哮喘中细胞衰老加速。本综述将主要通过讨论细胞衰老在哮喘中的潜在机制、衰老细胞对哮喘病理生物学的影响以及在哮喘患者中使用抗衰老疗法的有效性和可行性，汇编有关细胞衰老与哮喘潜在关系的当前研究结果。
