Liu Yanjun, Yang Lu, Guo Yongli, Zhang Ting, Qiao Xing, Wang Jingfeng, Xu Jie, Xue Changhu
College of Food Science and Engineering, Ocean University of China, 5 Yushan Road, Qingdao, Shandong 266003, People's Republic of China.
Qingdao National Laboratory for Marine Science and Technology, Qingdao, Shandong 266235, People's Republic of China.
J Agric Food Chem. 2020 Mar 18;68(11):3649-3655. doi: 10.1021/acs.jafc.0c00784. Epub 2020 Mar 6.
To develop hydrophilic astaxanthin with significantly enhanced solubility and stability, astaxanthin polyethylene glycol succinate (APGS) was synthesized by esterification of an astaxanthin succinate diester with polyethylene glycol 1000. The chemical structure of the hydrophilic derivative was confirmed by H nuclear magnetic resonance and mass spectra. APGS showed better solubility than free astaxanthin in water and enhanced bioavailability compared to that of free astaxanthin. Additionally, testing the effects on diabetes and inflammation in a high-fat- and high-sucrose-diet-induced insulin-resistant mouse model demonstrated its benefits, suggesting that APGS maintains the health-promoting properties of astaxanthin. These results suggest that APGS could be a better source of hydrophilic astaxanthin.
为了开发具有显著增强的溶解性和稳定性的亲水性虾青素，通过将虾青素琥珀酸二酯与聚乙二醇1000进行酯化反应合成了虾青素聚乙二醇琥珀酸酯（APGS）。通过氢核磁共振和质谱确认了亲水性衍生物的化学结构。与游离虾青素相比，APGS在水中表现出更好的溶解性，并且生物利用度有所提高。此外，在高脂高糖饮食诱导的胰岛素抵抗小鼠模型中测试其对糖尿病和炎症的影响，证明了其益处，这表明APGS保留了虾青素的健康促进特性。这些结果表明，APGS可能是亲水性虾青素的更好来源。
