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阻断 DNA 合成可导致 短暂增强细胞分裂。

Transient enhanced cell division by blocking DNA synthesis in .

机构信息

Departamento de Bioquímica Biología Molecular y Genética, Universidad de Extremadura, Badajoz 06071, Spain.

Present address: CICAB Clinical Research Centre, Extremadura University Hospital and Medical School, Badajoz, Spain.

出版信息

Microbiology (Reading). 2020 Jun;166(6):516-521. doi: 10.1099/mic.0.000888.

Abstract

Duplication of the bacterial nucleoid is necessary for cell division hence specific arrest of DNA replication inhibits divisions culminating in filamentation, nucleoid dispersion and appearance of a-nucleated cells. It is demonstrated here that during the first 10 min however, enhanced residual divisions: the proportion of constricted cells doubled (to 40%), nucleoids contracted and cells remodelled dimensions: length decreased and width increased. The preliminary data provides further support to the existence of temporal and spatial couplings between the nucleoid/replisome and the sacculus/divisome, and is consistent with the idea that bacillary bacteria modulate width during the division process exclusively.

摘要

细菌核区的复制对于细胞分裂是必要的,因此特定的 DNA 复制抑制剂会抑制分裂,导致丝状化、核区分散和出现无核细胞。这里证明,在最初的 10 分钟内,增强了剩余的分裂:收缩细胞的比例增加了一倍(达到 40%),核区收缩,细胞重塑了尺寸:长度减小,宽度增加。初步数据进一步支持核区/复制体和囊泡/分裂体之间存在时间和空间的偶联,并且与杆状细菌在分裂过程中专门调节宽度的观点一致。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bb8/7376268/451bbebd1cf4/mic-166-516-g001.jpg

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