Departamento de Bioquímica Biología Molecular y Genética, Universidad de Extremadura, Badajoz 06071, Spain.
Present address: CICAB Clinical Research Centre, Extremadura University Hospital and Medical School, Badajoz, Spain.
Microbiology (Reading). 2020 Jun;166(6):516-521. doi: 10.1099/mic.0.000888.
Duplication of the bacterial nucleoid is necessary for cell division hence specific arrest of DNA replication inhibits divisions culminating in filamentation, nucleoid dispersion and appearance of a-nucleated cells. It is demonstrated here that during the first 10 min however, enhanced residual divisions: the proportion of constricted cells doubled (to 40%), nucleoids contracted and cells remodelled dimensions: length decreased and width increased. The preliminary data provides further support to the existence of temporal and spatial couplings between the nucleoid/replisome and the sacculus/divisome, and is consistent with the idea that bacillary bacteria modulate width during the division process exclusively.
细菌核区的复制对于细胞分裂是必要的，因此特定的 DNA 复制抑制剂会抑制分裂，导致丝状化、核区分散和出现无核细胞。这里证明，在最初的 10 分钟内，增强了剩余的分裂：收缩细胞的比例增加了一倍（达到 40%），核区收缩，细胞重塑了尺寸：长度减小，宽度增加。初步数据进一步支持核区/复制体和囊泡/分裂体之间存在时间和空间的偶联，并且与杆状细菌在分裂过程中专门调节宽度的观点一致。
