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使用WatchPAT检测阻塞性睡眠呼吸暂停患者在持续气道正压通气(CPAP)治疗时隐匿性残留的睡眠呼吸紊乱情况。

Use of the WatchPAT to detect occult residual sleep-disordered breathing in patients on CPAP for obstructive sleep apnea.

作者信息

Epstein Matthew, Musa Tariq, Chiu Stephanie, Costanzo Jacquelyn, Dunne Christine, Cerrone Federico, Capone Robert

机构信息

Atlantic Health Sleep Centers, Livingston, New Jersey.

Atlantic Health System, Morristown, New Jersey.

出版信息

J Clin Sleep Med. 2020 Jul 15;16(7):1073-1080. doi: 10.5664/jcsm.8406.

Abstract

STUDY OBJECTIVES

To determine the accuracy of the apnea-hypopnea index (AHI) as measured by continuous positive airway pressure (CPAP) machines by simultaneously employing a home sleep apnea testing device (WatchPAT 200, Itamar Medical, Israel [WPAT]) in patients suspected of having residual sleep-disordered breathing (SDB).

METHODS

Patients with new, recurrent, or worsening signs, symptoms, or comorbidities associated with obstructive sleep apnea underwent home sleep apnea testing using WPAT while simultaneously using CPAP at their usual prescribed settings. CPAP AHI and WPAT AHI, respiratory disturbance index, and oximetry readings were then compared.

RESULTS

We identified an elevated AHI with WPAT testing in nearly half of patients with clinically suspected residual SDB and a normal CPAP AHI. WPAT detected additional respiratory events as well, including rapid eye movement-related apneas, respiratory effort-related arousals, and hypoxemia.

CONCLUSIONS

WPAT AHI was significantly higher than simultaneous CPAP AHI in nearly half of those patients with clinically suspected residual SDB being treated with CPAP. Additional respiratory disturbances, including rapid eye movement-related respiratory events, respiratory effort-related arousals, and hypoxemia, were elucidated only with the use of the WPAT. Residual SDB may have potential clinical consequences, including reduced CPAP adherence, ongoing hypersomnolence, and other health-related sequelae. Simultaneous WPAT testing of patients with a normal CPAP AHI may represent a valuable tool to detect clinically suspected residual SDB or to ensure adequate treatment in high-risk patients with obstructive sleep apnea in general.

摘要

研究目的

通过在疑似存在残余睡眠呼吸障碍(SDB)的患者中同时使用家用睡眠呼吸暂停检测设备(WatchPAT 200,以色列伊塔玛医疗公司[WPAT]),来确定持续气道正压通气(CPAP)机器所测量的呼吸暂停低通气指数(AHI)的准确性。

方法

有与阻塞性睡眠呼吸暂停相关的新的、复发的或恶化的体征、症状或合并症的患者,在按其通常规定的设置使用CPAP的同时,使用WPAT进行家用睡眠呼吸暂停检测。然后比较CPAP AHI和WPAT AHI、呼吸紊乱指数及血氧饱和度读数。

结果

我们发现在近一半临床上疑似存在残余SDB且CPAP AHI正常的患者中,WPAT检测显示AHI升高。WPAT还检测到了其他呼吸事件,包括快速眼动相关的呼吸暂停、呼吸努力相关的觉醒及低氧血症。

结论

在近一半接受CPAP治疗的临床上疑似存在残余SDB的患者中,WPAT AHI显著高于同时测量的CPAP AHI。仅使用WPAT才能发现包括快速眼动相关呼吸事件、呼吸努力相关觉醒及低氧血症在内的其他呼吸紊乱。残余SDB可能具有潜在的临床后果,包括CPAP依从性降低、持续的嗜睡及其他与健康相关的后遗症。对CPAP AHI正常的患者同时进行WPAT检测,可能是检测临床上疑似存在的残余SDB或确保一般阻塞性睡眠呼吸暂停高危患者得到充分治疗的一种有价值的工具。

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