Guan Anna, Richardson Steven, Hinckley Steven
J Opt Soc Am A Opt Image Sci Vis. 2020 Mar 1;37(3):391-398. doi: 10.1364/JOSAA.377121.
A direct scattering optical coherence tomography forward model was developed to simulate A-scans for both idealized and real light sources on an arbitrary given sample structure. Previous models neglected absorption, scattering, and multiple reflections at interfacial layers, and so two extended models were developed to investigate the impact of these processes. The first model uses the Beer-Lambert law to incorporate both absorption and scattering optical processes, and the second model uses a recursive form to model multiple reflections. These models were tested on a structure representative of a multilayered skin sample. The results show that the absorption and scattering processes have significant impact on the height of the peaks in the simulated A-scans. Conversely, the incorporation of multiple reflections has very little impact on the height of these peaks. Neither of the above processes has any impact on the locations of the A-scan peaks, which are associated with the sample interfaces between layers.
开发了一种直接散射光学相干断层扫描正向模型，以在任意给定的样本结构上模拟理想化光源和真实光源的A扫描。先前的模型忽略了界面层的吸收、散射和多次反射，因此开发了两个扩展模型来研究这些过程的影响。第一个模型使用比尔-朗伯定律来纳入吸收和散射光学过程，第二个模型使用递归形式来模拟多次反射。这些模型在代表多层皮肤样本的结构上进行了测试。结果表明，吸收和散射过程对模拟A扫描中峰值的高度有显著影响。相反，多次反射的纳入对这些峰值的高度影响很小。上述任何一个过程都不会对与层间样本界面相关的A扫描峰值位置产生任何影响。
