Swyer-James-MacLeod Syndrome

Swyer-James-MacLeod syndrome (SJMS), also known as Swyer-James syndrome or hyperlucent lung syndrome, is an uncommon syndrome of unilateral functional hypoplasia of the pulmonary vasculature and emphysema, with or without associated bronchiectasis. The condition was first described simultaneously in the 1950s by a respiratory physician William Mathieson Macleod in England (1954), and by a physician Paul Robert Swyer and a radiologist George James in Canada (1953). This rare lung condition is characterized by the radiographic hyperlucent appearance of a single pulmonary lobe or the entire lung. It is considered to arise as a postinfectious complication of bronchiolitis obliterans in childhood.