Wang Chunguang, Bai Meiling, Sun Zhiguang, Yao Nan, Zhang Aiting, Guo Shengyu, Asemi Zatollah
The First Affiliated Hospital of Hebei North University, Zhang Jiakou, 075000, Hebei, China.
Basic Medical College of Hebei North University, Zhang Jiakou, 075000, Hebei, China.
Cancer Cell Int. 2023 Oct 14;23(1):241. doi: 10.1186/s12935-023-03081-8.
MicroRNAs (miRNAs) are a group of small non-coding RNAs that affect gene expression. The role of miRNAs in different types of cancers has been published and it was shown that several miRNAs are inappropriately expressed in different cancers. Among the mechanisms that can cause this lack of proper expression are epigenetics, chromosomal changes, polymorphisms or defects in processing proteins. Recent research shows that phytochemicals, including epigallocatechin-3-gallate (EGCG), exert important epigenetic-based anticancer effects such as pro-apoptotic or anti proliferative through miRNA gene silencing. Given that EGCG is able to modulate a variety of cancer-related process i.e., angiogenesis, proliferation, metastasis and apoptosis via targeting various miRNAs such as let-7, miR-16, and miR-210. The discovery of new miRNAs and the differences observed in their expression when exposed to EGCG provides evidence that targeting these miRNAs may be beneficial as a form of treatment. In this review, we aim to provide an overview, based on current knowledge, on how phytochemicals, including epigallocatechin-3-gallate, can be considered as potential miRNAs modulator to improve efficacy of current cancer treatments.
微小RNA（miRNA）是一类影响基因表达的小型非编码RNA。miRNA在不同类型癌症中的作用已有相关报道，结果显示几种miRNA在不同癌症中存在异常表达。导致这种正常表达缺失的机制包括表观遗传学、染色体变化、多态性或加工蛋白缺陷。最近的研究表明，包括表没食子儿没食子酸酯（EGCG）在内的植物化学物质可通过miRNA基因沉默发挥重要的基于表观遗传学的抗癌作用，如促凋亡或抗增殖作用。鉴于EGCG能够通过靶向let-7、miR-16和miR-210等多种miRNA来调节多种癌症相关过程，即血管生成、增殖、转移和凋亡。新miRNA的发现以及暴露于EGCG时其表达的差异表明，靶向这些miRNA可能作为一种治疗形式有益。在本综述中，我们旨在基于现有知识概述包括表没食子儿没食子酸酯在内的植物化学物质如何被视为潜在的miRNA调节剂，以提高当前癌症治疗的疗效。
