Innovation Center of the Faculty of Chemistry, University of Belgrade, Studentski trg 12-16, Belgrade, Serbia.
University of Belgrade - Faculty of Chemistry, Studentski trg 12-16, Belgrade, Serbia.
Sci Rep. 2020 Mar 2;10(1):3816. doi: 10.1038/s41598-020-60774-0.
The pathogenesis of malignant brain tumors (MBTs) should be better understood due to the evident association between prolonged exposure to metals and increased risk of MBTs. The present research aimed to find trace metals that could contribute to the pathogenesis of MBTs. Essential trace elements (Mn, Co, Zn, Cu, Se) and relevant toxic metals (Al, Ni, As, Sr, Cd, Ce, Pt, Pb, U) in the serum, cell fraction (CF), cerebrospinal fluid (CSF) and cancerous tissue (CT) samples of MBT patients were analyzed. The results were compared with sex- and age-matched control groups. For the first time, this research showed that elemental profiles of serum, CF, CSF and CT samples in MBT patients were significantly altered compared to the appropriate controls, as well as that higher contents of trace elements (particularly Mn, Se, and Pb) could be involved in the pathogenesis of MBTs. However, the most noticeable change found was the elevated U content, indicating its considerable role as a major cerebral discriminator of the presence/absence of MBTs. The U/Se ratio could be considered as an appropriate blood marker in diagnostic MBT evaluation. The reported results could contribute to better understanding of the poorly understood pathogenesis of MBTs. Furthermore, the reported results could highlight a molecular basis for the pathophysiological changes caused by the hazardous effects of trace metals on brain homeostasis.
由于长期接触金属与恶性脑肿瘤（MBTs）风险增加之间存在明显关联，因此应更好地了解恶性脑肿瘤的发病机制。本研究旨在寻找可能导致 MBT 发病机制的痕量金属。分析了 MBT 患者血清、细胞部分（CF）、脑脊液（CSF）和癌组织（CT）样本中的必需痕量元素（Mn、Co、Zn、Cu、Se）和相关毒性金属（Al、Ni、As、Sr、Cd、Ce、Pt、Pb、U）。将结果与性别和年龄匹配的对照组进行比较。这是首次研究表明，与适当的对照相比，MBT 患者的血清、CF、CSF 和 CT 样本的元素谱明显改变，并且痕量元素（特别是 Mn、Se 和 Pb）的含量较高可能与 MBT 的发病机制有关。然而，发现的最明显变化是 U 含量升高，表明其作为 MBT 存在/不存在的主要大脑鉴别物具有相当大的作用。U/Se 比值可作为诊断 MBT 评估的适当血液标志物。报告的结果有助于更好地了解 MBT 发病机制尚不清楚的原因。此外，报告的结果可能突出了痕量金属对脑内稳态的有害影响引起的病理生理变化的分子基础。
