Tebuka Erius, Fulgence Ruharara D, Msemwa Bertrand, Silago Vitus, Mshana Stephen E, Mirambo Mariam M
Department of Pathology, Weill Bugando School of Medicine, Catholic University of Health and Allied Sciences, P.O. Box 1464, Mwanza, Tanzania.
Department of Microbiology and Immunology, Weill Bugando School of Medicine, Catholic University of Health and Allied Sciences, P.O. Box 1464, Mwanza, Tanzania.
Afr Health Sci. 2019 Sep;19(3):2351-2355. doi: 10.4314/ahs.v19i3.7.
Despite blood transfusion being a lifesaving option, it may be associated with blood borne infections including human cytomegalovirus(HCMV). The World Health Organization recommends screening of blood products for HCMV before transfusion to pregnant women, neonates and immunocompromised patients. However, this is not routinely practised in many resource limited countries.
This study aimed at determining seroprevalence of specific HCMV IgM antibodies among volunteered blood donors at the Lake Victoria zone blood transfusion centre.
A total of 228 sera from volunteered blood donors were analyzed using HCMV IgM µ capture enzyme linked immunosorbent assay as per manufacturer's instructions. Data were analyzed by STATA version 13.
The median age of the study participants was 19 interquartile range (IQR): 18-23 years. The seroprevalence of specific HCMV IgM antibodies was found to be 23/228 (10.1%, 95% confidence interval (CI): 6-14. None of the factors was found to be associated with HCMV IgM seropositivity among blood donors.
One out 10 blood donors in the Lake Victoria zone blood transfusion centre is acutely infected with HCMV. There is a need to consider screening of HCMV before blood transfusion particularly in resource limited countries where HCMV is endemic.
尽管输血是一种挽救生命的选择，但它可能与包括人类巨细胞病毒（HCMV）在内的血源性感染有关。世界卫生组织建议在给孕妇、新生儿和免疫功能低下的患者输血前对血液制品进行HCMV筛查。然而，在许多资源有限的国家，这并没有常规实施。
本研究旨在确定维多利亚湖地区输血中心无偿献血者中特定HCMV IgM抗体的血清流行率。
按照制造商的说明，使用HCMV IgM μ捕获酶联免疫吸附试验对228份无偿献血者的血清进行分析。数据采用STATA 13版进行分析。
研究参与者的年龄中位数为19岁，四分位间距（IQR）为18 - 23岁。特定HCMV IgM抗体的血清流行率为23/228（10.1%，95%置信区间（CI）：6 - 14）。未发现任何因素与献血者中的HCMV IgM血清阳性相关。
维多利亚湖地区输血中心每10名献血者中就有1人急性感染HCMV。特别是在HCMV流行的资源有限国家，有必要考虑在输血前对HCMV进行筛查。
