不同溶剂混合物和碱浓度条件下合成羧甲基纤维素钠的特性研究
Characterization of Synthesized Sodium Carboxymethyl Cellulose with Variation of Solvent Mixture and Alkali Concentration.
作者信息
Wahyuni Henny Sri, Yuliasmi Sri, Aisyah Hanifah Siti, Riati Devi
机构信息
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Sumatera Utara, Medan 20155, Indonesia.
出版信息
Open Access Maced J Med Sci. 2019 Nov 14;7(22):3878-3881. doi: 10.3889/oamjms.2019.524. eCollection 2019 Nov 30.
BACKGROUND
CMC is one of the water-soluble polysaccharide derivatives obtained from cellulose. Alkalization and carboxymethylation process will influence the quality of the CMC. The use of a combination of mixed solvents and varying alkali concentrations in the synthesis process of CMC needs to be studied so that CMC can be synthesized with the proper characteristics.
AIM
This study was conducted to determine the characteristics of carboxymethyl cellulose synthesized using various solvents and NaOH concentrations.
METHODS
Carboxymethyl cellulose (CMC) was synthesized using solvent mixture, namely isopropanol: isobutanol (30: 70) and isopropanol:ethanol (50: 50) with varied concentration of NaOH of 5%, 10%, 15%, 20%, 25%, respectively. Synthesized CMC was characterized by an organoleptic test, pH, infrared analysis, and degree of substitution (DS).
RESULTS
The result showed that characteristics of synthesized CMC were different from one another. The organoleptic test showed that synthesized CMC uses isopropanol: isobutanol (30: 70) was coarse powder, odourless and tasteless, ivory until burlywood along with increasing NaOH concentration; while the synthesized CMC with isopropanol: ethanol (50: 50) was a colourless, odourless, tasteless and fine powder. The pH of synthesized CMC was neutral. Infrared profile of synthesized CMC indicated the existence of carboxyl functional groups in 1600-1640 cm region. The degree of substitution value of formula II-5, II-10, II-15, II-20, II-25, IE-5, IE-10, IE-15, IE-20, and IE-25 were 0.885;0.757; 0.685; 0.592; 0.575; 0.611; 0.906; 0.603; 0.671; 0.751, respectively.
CONCLUSION
Characteristics of CMC vary depending on the type of solvent mixture and NaOH concentrations used in synthesis. The more polarity of a solvent mixture the more colourless and higher DS value of synthesized CMC. On the other hand, the more alkali concentration in synthesis CMC the more colour and higher DS value was acquired.
背景
羧甲基纤维素（CMC）是从纤维素中获得的水溶性多糖衍生物之一。碱化和羧甲基化过程会影响CMC的质量。需要研究在CMC合成过程中混合溶剂和不同碱浓度的组合使用情况，以便能够合成具有适当特性的CMC。
目的
本研究旨在确定使用各种溶剂和氢氧化钠浓度合成的羧甲基纤维素的特性。
方法
使用溶剂混合物合成羧甲基纤维素（CMC），即异丙醇：异丁醇（30:70）和异丙醇：乙醇（50:50），氢氧化钠浓度分别为5%、10%、15%、20%、25%。通过感官测试、pH值、红外分析和取代度（DS）对合成的CMC进行表征。
结果
结果表明，合成的CMC的特性各不相同。感官测试表明，使用异丙醇：异丁醇（30:70）合成的CMC为粗粉，无味无臭，随着氢氧化钠浓度的增加，颜色从象牙色到淡黄褐色；而使用异丙醇：乙醇（50:50）合成的CMC为无色、无味、无臭的细粉。合成的CMC的pH值呈中性。合成的CMC的红外图谱表明在1600 - 1640 cm区域存在羧基官能团。式II - 5、II - 10、II - 15、II - 20、II - 25、IE - 5、IE - 10、IE - 15、IE - 20和IE - 25的取代度值分别为0.885；0.757；0.685；0.592；0.575；0.611；0.906；0.603；0.671；0.751。
结论
CMC的特性取决于合成中使用的溶剂混合物类型和氢氧化钠浓度。溶剂混合物的极性越大，合成的CMC越无色且取代度值越高。另一方面，合成CMC时碱浓度越高，获得的颜色越深且取代度值越高。
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