Smell and Taste Clinic, Department of Otorhinolaryngology, Technische Universität Dresden, Fetscherstrasse 74, 01307, Dresden, Germany.
Klinik für Hals-Nasen und Ohrenheilkunde, Universitätsklinikum Gießen und Marburg, Standort Marburg, Germany.
Eur Arch Otorhinolaryngol. 2020 Jun;277(6):1675-1680. doi: 10.1007/s00405-020-05874-3. Epub 2020 Mar 4.
Research indicates that rheumatic disorders are accompanied by decreased chemosensory function. The present study aimed to specifically evaluate this issue in patients with rheumatoid arthritis (RA).
212 RA patients (43 men, 169 women, mean age 59 ± 13.3 years), and 30 healthy controls (10 men, 20 women, mean age 40 ± 15.3 years), were included in this study. Chemosensory measurements consisted of olfactory testing using the "Sniffin' Sticks" test battery (with odor thresholds, odor discrimination and odor identification; OT, OD, OI) and gustatory testing on a suprathreshold and a quasi-threshold level using "taste sprays" and "taste strips", respectively. In addition, inflammatory markers (erythrocyte sedimentation rate, C-reactive protein) and RA autoantibodies (anti-cyclic citrullinated peptides, RA factors) were evaluated.
Olfactory measurements showed 4% of the RA patients functionally anosmic and 40% hyposmic. RA patients scored significantly lower in suprathreshold olfactory tests (OD, OI) compared to controls (OI: 12.5 ± 2.5 vs. 14.1 ± 1.3; OD: 11.3 ± 2.7 vs. 12.9 ± 1.7). In addition, RA patient had decreased taste function compared to healthy individuals (10.4 ± 2.6 vs. 11.7 ± 1.7). Chemosensory function did not correlate with parameters related to the severity of disease.
Chemosensory function (taste, OD and OI) appears to be decreased in RA patients. In contrast, OT was not affected. Changes in chemosensory function seem to be independent of disease parameters such as duration of disease or disease activity.
研究表明，风湿性疾病伴有化学感觉功能下降。本研究旨在专门评估类风湿关节炎（RA）患者的这一问题。
本研究纳入了 212 名 RA 患者（43 名男性，169 名女性，平均年龄 59±13.3 岁）和 30 名健康对照者（10 名男性，20 名女性，平均年龄 40±15.3 岁）。化学感觉测量包括使用“Sniffin' Sticks”测试试剂盒进行嗅觉测试（嗅觉阈值、嗅觉辨别和嗅觉识别；OT、OD、OI），以及使用“味觉喷雾器”和“味觉条”在阈上和准阈水平上进行味觉测试。此外，还评估了炎症标志物（红细胞沉降率、C 反应蛋白）和 RA 自身抗体（抗环瓜氨酸肽、RA 因子）。
嗅觉测量结果显示，4%的 RA 患者嗅觉功能丧失，40%嗅觉减退。与对照组相比，RA 患者在阈上嗅觉测试（OD、OI）中的得分显著较低（OI：12.5±2.5 与 14.1±1.3；OD：11.3±2.7 与 12.9±1.7）。此外，RA 患者的味觉功能较健康个体下降（10.4±2.6 与 11.7±1.7）。化学感觉功能与疾病严重程度相关的参数无相关性。
RA 患者的化学感觉功能（味觉、OD 和 OI）似乎下降，而 OT 不受影响。化学感觉功能的变化似乎与疾病参数（如疾病持续时间或疾病活动度）无关。
