Department of Experimental Medicine, Unit of Respiratory Medicine, University of Rome "Tor Vergata", Rome, Italy.
Imperial College London and Royal Brompton Hospital, Airways Disease Section, National Heart and Lung Institute (NHLI), London, UK.
Expert Opin Drug Deliv. 2020 May;17(5):635-646. doi: 10.1080/17425247.2020.1739021. Epub 2020 Mar 16.
: Proper device selection is crucial for the clinical results of inhalation therapy. However, none of the available devices fully conforms to the requirements for delivering drug with increased patient adherence, and we are still looking for the ideal inhaler. For this reason, there are several ongoing technical innovations to improve inhaler devices.: Progress in pulmonary drug delivery device technology is examined, focusing on innovations in pressurized metered dose inhalers, dry powder inhalers, nebulizers, and soft mist inhalers.: Both formulation improvements and new device technologies have been developed over the last couple of decades through an improved understanding of the mechanisms of aerosolization and lung deposition. Digital health is offering the potential to produce inhalers with a wider range of monitoring capabilities, but further studies are needed, in particular as regards the analysis of cost-effectiveness. Furthermore, there are still substantial issues that must be overcome in order to continually innovate and improve targeted inhaled drug delivery to the lungs. In any case, there are other potential therapeutic possibilities for COPD in development that may be administered by inhalation, whose clinical use requires advances and improvements in the devices used for administration.
: 正确的装置选择对于吸入疗法的临床效果至关重要。然而，目前尚无任何一种可用的装置完全符合提高患者依从性的药物输送要求，我们仍在寻找理想的吸入器。出于这个原因，正在进行一些技术创新以改进吸入器装置。: 本文综述了肺部药物输送装置技术的进展，重点介绍了加压计量吸入器、干粉吸入器、雾化器和软雾吸入器的创新。: 在过去的几十年中，通过对气溶胶化和肺部沉积机制的深入了解，已经开发出了改进的制剂和新的装置技术。数字健康为生产具有更广泛监测能力的吸入器提供了潜力，但还需要进一步研究，特别是在成本效益分析方面。此外，为了不断创新并改善肺部靶向药物输送，仍有许多重大问题需要克服。无论如何，COPD 仍有其他潜在的治疗可能性可以通过吸入给药，其临床应用需要在给药装置方面取得进展和改进。
