CEDOC, Chronic Diseases Research Centre, NOVA Medical School | Faculdade de Ciências Médicas, Universidade NOVA de Lisboa, Lisbon, Portugal.
Instituto Português de Oncologia de Lisboa Francisco Gentil (IPOLFG), Lisbon, Portugal.
Adv Exp Med Biol. 2020;1219:77-91. doi: 10.1007/978-3-030-34025-4_4.
Several aspects of the human physiology are controlled by the microbiota that plays a key role in health and disease. In fact, microbial dysbiosis is associated with numerous diseases, including several types of cancer such as colon, gastric, esophageal, pancreatic, laryngeal, breast and gallbladder carcinomas.Metabolic symbiosis between non-malignant cells and the resident microbita is crucial for the host homeostasis. However, cancer cells are able to repurpose the pre-existing metabolic symbiosis, being able to recycle those relations and also create novel metabolic symbiosis, leading to profound alterations on the local microenvironment.In here we will explore some of these symbiotic metabolic interactions between bacteria and non-malignant cells in two different contexts: colon and uterine cervix. The way malignant cells are able to recycle these normal interactions and also create novel types of symbiotic metabolic relations will also be discussed.The knowledge of these complex interactions and recycling mechanisms is of extreme importance for cancer treatment, as new therapeutic targets could be developed.
人体生理学的几个方面受到在健康和疾病中发挥关键作用的微生物群的控制。事实上，微生物失调与许多疾病有关，包括多种癌症，如结肠癌、胃癌、食管癌、胰腺癌、喉癌、乳腺癌和胆囊癌。非恶性细胞与常驻微生物之间的代谢共生对于宿主内环境稳定至关重要。然而，癌细胞能够重新利用现有的代谢共生关系，能够回收这些关系并创建新的代谢共生关系，导致局部微环境发生深刻改变。在这里，我们将探讨两种不同情况下细菌和非恶性细胞之间的一些共生代谢相互作用：结肠和子宫颈。还将讨论恶性细胞如何能够回收这些正常的相互作用并创建新型共生代谢关系。了解这些复杂的相互作用和回收机制对于癌症治疗非常重要，因为可以开发新的治疗靶点。
