Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, UK.
Proteomics of Non-Model Organisms Lab, ITQB Nova-Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Oeiras, Portugal.
Adv Exp Med Biol. 2020;1219:367-385. doi: 10.1007/978-3-030-34025-4_19.
Altered metabolism is one of the key hallmarks of cancer. The development of sensitive, reproducible and robust bioanalytical tools such as Nuclear Magnetic Resonance Spectroscopy and Mass Spectrometry techniques offers numerous opportunities for cancer metabolism research, and provides additional and exciting avenues in cancer diagnosis, prognosis and for the development of more effective and personalized treatments. In this chapter, we introduce the current state of the art of metabolomics and metabolic phenotyping approaches in cancer research and clinical diagnostics.
代谢改变是癌症的一个关键特征。核磁共振波谱和质谱等灵敏、可重现和稳健的生物分析工具的发展为癌症代谢研究提供了众多机会，并为癌症诊断、预后以及开发更有效和个性化的治疗方法提供了更多令人兴奋的途径。在本章中，我们介绍了代谢组学和代谢表型分析方法在癌症研究和临床诊断中的最新进展。
