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调节肿瘤微环境的代谢表型。

Modulating the Metabolic Phenotype of Cancer Microenvironment.

机构信息

Instituto de Medicina Molecular João Lobo Antunes, Universidade de Lisboa, Lisbon, Portugal.

出版信息

Adv Exp Med Biol. 2020;1219:403-411. doi: 10.1007/978-3-030-34025-4_21.

Abstract

This chapter provides a brief overview of the methods to study and modulate the metabolic phenotype of the tumor microenvironment, including own research work to demonstrate the impact that metabolic shifts in the host have on cancer. Firstly, we briefly discuss the relevance of using animal models to address this topic, and also the importance of acknowledging that animals have diverse metabolic phenotypes according to species, and even with strain, age or sex. We also present original data to highlight the impact that changes in metabolic phenotype of the microenvironment have on tumor progression. Using an acute leukemia mouse xenograft model and high-fat diet we show that a shift in the host metabolic phenotype, induced by high-fat feeding, significantly impacts on tumor progression. The mechanism through which this occurs involves a direct effect of the increased levels of circulating lipoproteins in both tumor and non-neoplastic cells.

摘要

本章简要概述了研究和调节肿瘤微环境代谢表型的方法,包括作者自己的研究工作,以证明宿主代谢变化对癌症的影响。首先,我们简要讨论了使用动物模型来解决这一问题的相关性,以及承认动物根据物种,甚至根据品系、年龄或性别,具有不同代谢表型的重要性。我们还提供了原始数据,以强调微环境代谢表型的变化对肿瘤进展的影响。我们使用急性髓系白血病小鼠异种移植模型和高脂肪饮食,表明高脂肪喂养引起的宿主代谢表型的改变,显著影响肿瘤的进展。发生这种情况的机制涉及循环脂蛋白在肿瘤和非肿瘤细胞中的水平增加所产生的直接作用。

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