Molecular Oncology Laboratories, University Department of Oncology, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, UK.
Br J Cancer. 2012 Oct 9;107(8):1207-12. doi: 10.1038/bjc.2012.398.
Tumour tissue is characterised by fluctuating oxygen concentrations, decreased nutrient supply, and acidic pH. The primarily glycolytic metabolism of tumour cells contributes to this, with increased glucose consumption and increased lactate secretion. Endothelial cells are particularly challenged when recruited towards the tumour metabolic environment. They are required to proliferate and form functional networks in order to establish continuous blood flow. Considering that deregulated metabolism is an emerging hallmark of cancer and target of tumour therapy, it is of importance to incorporate the current knowledge about how the tumour metabolic environment, as a therapy target, can affect endothelial cell metabolism and the angiogenic response. Recent studies have shown differences in metabolic pathways in endothelial cells compared with other normal or tumour tissues. Therefore, we have reviewed relevant literature on endothelial metabolism and the response to angiogenic activation in conditions of metabolic stress.
肿瘤组织的特点是氧浓度波动、营养供应减少和酸性 pH 值。肿瘤细胞的主要糖酵解代谢导致了这一点，表现为葡萄糖消耗增加和乳酸分泌增加。内皮细胞在向肿瘤代谢环境募集时受到特别的挑战。它们需要增殖并形成功能网络，以建立持续的血流。考虑到代谢失调是癌症的一个新兴标志和肿瘤治疗的靶点，了解肿瘤代谢环境作为治疗靶点如何影响内皮细胞代谢和血管生成反应非常重要。最近的研究表明，内皮细胞的代谢途径与其他正常或肿瘤组织存在差异。因此，我们回顾了有关内皮细胞代谢以及在代谢应激条件下对血管生成激活反应的相关文献。
