Department of Pharmacology, University of North Carolina Chapel Hill Medical School, Chapel Hill, NC 27514, USA.
Department of Pharmacology, University of North Carolina Chapel Hill Medical School, Chapel Hill, NC 27514, USA.
Structure. 2020 Mar 3;28(3):277-279. doi: 10.1016/j.str.2020.02.004.
Ma et al. (2020) and Liang et al. (2020) describe the cryo-EM structures of three class B G protein-coupled receptors (GPCRs) in complex with native peptides and Gs. Their work establishes the structural basis of peptide specificity and a conserved mechanism of receptor activation and G protein coupling for class B GPCRs.
马等人（2020 年）和梁等人（2020 年）描述了三种与天然肽和 Gs 复合物的 B 类 G 蛋白偶联受体（GPCR）的冷冻电镜结构。他们的工作为 B 类 GPCR 的肽特异性和受体激活以及 G 蛋白偶联的保守机制奠定了结构基础。
