Department of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Department of Gastroenterology, Asahi University Hospital, Gifu, Japan.
Kidney Blood Press Res. 2020;45(2):339-349. doi: 10.1159/000504545. Epub 2020 Mar 4.
The duration of sleep might be a risk factor for chronic kidney disease (CKD). We investigated the relationship between sleep duration and incident CKD.
In this retrospective cohort study of 7,752 men and 6,722 women, we divided the subjects into 4 groups according to sleep duration, i.e., those whose reported regular sleep duration was <6 h (the "<6 h group"), those whose sleep duration was >6 but <7 h (the "6 to <7 h group"), those with a sleep duration of 7 to <8 h (the "7 to <8 h group"), and those with ≥8 h sleep (the "≥8 h group"). CKD was defined as the presence of proteinuria and/or an estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m2. The HR of the 4 groups for incident CKD were calculated with a Cox proportional hazards model, with the 7 to <8 h group set as the reference.
Incident CKD was detected in 1,513 (19.5%) men and 688 (10.2%) women over the median follow-up period of 7.0 (3.3-11.9) years in the men and 6.7 (3.1-10.8) years in the women. There was no association between sleep duration and incident CKD in the women. In the men, the HR of incident CKD was 0.54 (95% CI 0.45-0.64, p < 0.001) in the <6 h group, 0.73 (95% CI 0.66-0.82, p < 0.001) in the 6 to <7 h group, and 0.93 (95% CI 0.78-1.11, p = 0.433) in the ≥8 h group.
The risk of incident CKD is lowest in those who sleep <6 h. We revealed that the risk of incident CKD is lowest in those who sleep <6 h among apparently healthy men.
睡眠持续时间可能是慢性肾脏病（CKD）的一个危险因素。我们研究了睡眠持续时间与 CKD 发病之间的关系。
在这项对 7752 名男性和 6722 名女性进行的回顾性队列研究中，我们根据睡眠持续时间将受试者分为 4 组，即报告的睡眠时间<6 小时（<6 小时组）、睡眠时间>6 但<7 小时（6 至<7 小时组）、睡眠时间 7 至<8 小时（7 至<8 小时组）和睡眠时间≥8 小时（≥8 小时组）。CKD 的定义为蛋白尿和/或估计肾小球滤过率（eGFR）<60 mL/min/1.73 m2。使用 Cox 比例风险模型计算 4 组发生 CKD 的 HR，以 7 至<8 小时组为参考。
在中位随访时间为男性 7.0（3.3-11.9）年和女性 6.7（3.1-10.8）年后，男性中 1513 名（19.5%）和女性中 688 名（10.2%）发生了 CKD 事件。女性的睡眠时间与 CKD 发病之间没有关联。在男性中，<6 小时组发生 CKD 的 HR 为 0.54（95%CI 0.45-0.64，p<0.001），6 至<7 小时组为 0.73（95%CI 0.66-0.82，p<0.001），≥8 小时组为 0.93（95%CI 0.78-1.11，p=0.433）。
睡眠<6 小时者发生 CKD 的风险最低。我们发现，在健康男性中，睡眠<6 小时者发生 CKD 的风险最低。
