Department of Pathology, Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.
Department of Hematology and Oncology, Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2020 Jul;12(4):e1621. doi: 10.1002/wnan.1621. Epub 2020 Mar 4.
Under the broader category of extracellular vesicles (EVs), exosomes are now well recognized for their contribution and potential for biomedical research. During the last ten years, numerous technologies for purification and characterization of EVs have been developed. This enhanced knowledge has resulted in the development of novel applications of EVs. This review is an attempt to capture the exponential growth observed in EV science in the last decade and discuss the future potential to improve our understanding of EVs, develop technologies to overcome current limitations, and advance their utility for human benefit, especially in cancer medicine. This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease.
在细胞外囊泡(EVs)的更广泛类别下,外泌体现在因其对生物医学研究的贡献和潜力而得到充分认可。在过去的十年中,已经开发出许多用于 EV 纯化和表征的技术。这些知识的增强导致了 EV 新应用的发展。本综述试图捕捉过去十年中 EV 科学中观察到的指数级增长,并讨论未来提高我们对 EV 理解、开发克服当前限制的技术以及推进其用于人类利益的潜力,特别是在癌症医学方面。本文属于以下类别:治疗方法和药物发现 > 新兴技术治疗方法和药物发现 > 用于肿瘤疾病的纳米医学。