Yang Kai Li, Sun Zhao, Bai Chun Mei, Zhao Lin
Department of Medical Oncology,PUMC Hospital,CAMS and PUMC,Beijing 100032,China.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2020 Feb 28;42(1):117-123. doi: 10.3881/j.issn.1000-503X.11194.
Tumors are highly complex systems. Understanding the compositions and functions of the tumor immune microenvironment is a prerequisite for effective tumor immunotherapy. Single-cell RNA sequencing can detect the transcriptome of a cell at the resolution of single-cell level,describe its functional status,and thus deepen the understanding of the composition and function of different cell clusters in tumor immune microenvironment. This article reviews the application of single-cell RNA sequencing in research on tumor immune microenvironment.
肿瘤是高度复杂的系统。了解肿瘤免疫微环境的组成和功能是有效的肿瘤免疫治疗的前提条件。单细胞RNA测序能够在单细胞水平分辨率下检测细胞的转录组，描述其功能状态，从而加深对肿瘤免疫微环境中不同细胞簇的组成和功能的理解。本文综述了单细胞RNA测序在肿瘤免疫微环境研究中的应用。
