Meske S, Bänziger E
Abtl. Rheumatologie und klinische Immunologie, Medizinische Universitätskliniken, Freiburg.
Z Rheumatol. 1988 May-Jun;47(3):146-50.
The supernatant of peripheral blood monocytes, cultured with autologous sera from patients with rheumatoid arthritis, stimulates healthy human granulocytes to significantly elevated chemiluminescence (p = 0.05) compared with supernatants of monocytes from osteoarthritic patients or healthy volunteers. Cultures without autologous sera or with heat-inactivated sera demonstrate this effect less significantly (p = 0.05). The peak chemiluminescence is slightly correlated with the titer of rheumatoid factor (r = 0.42 in latex fixation, r = 0.45 in the Waaler-Rose test). The elevated release of monokines, especially interleukin I from monocytes of rheumatoid arthritis patients triggered by rheumatoid factors, immunocomplexes, complement compounds and other serum factors, may explain the phenomenon.
用类风湿性关节炎患者的自体血清培养的外周血单核细胞的上清液，与骨关节炎患者或健康志愿者的单核细胞上清液相比，能刺激健康人粒细胞产生显著升高的化学发光（p = 0.05）。没有自体血清或使用热灭活血清的培养物显示这种效应不太显著（p = 0.05）。化学发光峰值与类风湿因子滴度呈轻微相关（乳胶凝集法中r = 0.42，瓦勒 - 罗斯试验中r = 0.45）。类风湿因子、免疫复合物、补体成分和其他血清因子引发的类风湿性关节炎患者单核细胞中单核因子，尤其是白细胞介素I的释放增加，可能解释了这一现象。
