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一名成年患者颈部肺泡横纹肌肉瘤的罕见病例。

An Unusual Case of Alveolar Rhabdomyosarcoma of the Neck in an Adult Patient.

作者信息

Wazir Mohammed, Jain Akriti G, FaisalUddin Mohammed, Tambunan Daniel

机构信息

Internal Medicine, Brigham and Women's Hospital, Boston, USA.

Internal Medicine, AdventHealth, Orlando, USA.

出版信息

Cureus. 2020 Jan 22;12(1):e6745. doi: 10.7759/cureus.6745.

DOI:10.7759/cureus.6745
PMID:32133267
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7034753/
Abstract

Rhabdomyosarcoma is the most common soft tissue malignancy in adolescents. It is extremely rare for sarcomas to occur in patients more than 18 years of age. We present a case of rhabdomyosarcoma originating in skeletal muscles on the right side of the neck. Our case demonstrates the importance of considering an extensive differential diagnosis for a neck mass in adults. Our patient was diagnosed with alveolar variant of rhabdomyosarcoma and underwent chemotherapy and radiation therapy, but eventually due to recurrence opted for palliative therapy.

摘要

横纹肌肉瘤是青少年中最常见的软组织恶性肿瘤。肉瘤在18岁以上的患者中极为罕见。我们报告一例起源于颈部右侧骨骼肌的横纹肌肉瘤病例。我们的病例表明，对于成人颈部肿块，进行广泛鉴别诊断的重要性。我们的患者被诊断为横纹肌肉瘤的腺泡状变种，并接受了化疗和放疗，但最终因复发而选择了姑息治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d03/7034753/16d59f45aba0/cureus-0012-00000006745-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d03/7034753/5c131735aab5/cureus-0012-00000006745-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d03/7034753/59b4e9886e74/cureus-0012-00000006745-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d03/7034753/bdd8ac613728/cureus-0012-00000006745-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d03/7034753/16d59f45aba0/cureus-0012-00000006745-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d03/7034753/5c131735aab5/cureus-0012-00000006745-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d03/7034753/59b4e9886e74/cureus-0012-00000006745-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d03/7034753/bdd8ac613728/cureus-0012-00000006745-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d03/7034753/16d59f45aba0/cureus-0012-00000006745-i04.jpg

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本文引用的文献

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Growing Role of Regorafenib in the Treatment of Patients with Sarcoma.雷戈非尼在肉瘤患者治疗中的作用不断增加。
Target Oncol. 2018 Aug;13(4):417-422. doi: 10.1007/s11523-018-0575-0.
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Sinonasal Tract Alveolar Rhabdomyosarcoma in Adults: A Clinicopathologic and Immunophenotypic Study of Fifty-Two Cases with Emphasis on Epithelial Immunoreactivity.成人鼻窦肺泡横纹肌肉瘤：52例临床病理及免疫表型研究，重点关注上皮免疫反应性
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Rhabdomyosarcoma in adolescent and young adult patients: current perspectives.青少年和青年成人患者的横纹肌肉瘤：当前观点
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Phase 1 trial of temsirolimus in combination with irinotecan and temozolomide in children, adolescents and young adults with relapsed or refractory solid tumors: a Children's Oncology Group Study.替西罗莫司联合伊立替康和替莫唑胺治疗复发或难治性实体瘤患儿、青少年和年轻成人的 1 期临床试验：一项儿童肿瘤学组研究。
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Classification of rhabdomyosarcoma and its molecular basis.横纹肌肉瘤的分类及其分子基础。
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Rhabdomyosarcoma: review of the Children's Oncology Group (COG) Soft-Tissue Sarcoma Committee experience and rationale for current COG studies.横纹肌肉瘤：儿童肿瘤学组（COG）软组织肉瘤委员会经验回顾及当前 COG 研究的原理。
Pediatr Blood Cancer. 2012 Jul 15;59(1):5-10. doi: 10.1002/pbc.24118. Epub 2012 Feb 29.
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Epithelioid rhabdomyosarcoma: clinicopathologic analysis of 16 cases of a morphologically distinct variant of rhabdomyosarcoma.上皮样横纹肌肉瘤：形态学独特变异型横纹肌肉瘤 16 例的临床病理分析。
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Comparing adult and pediatric rhabdomyosarcoma in the surveillance, epidemiology and end results program, 1973 to 2005: an analysis of 2,600 patients.1973年至2005年监测、流行病学和最终结果计划中成人与儿童横纹肌肉瘤的比较：2600例患者的分析
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