亚急性敌敌畏中毒对老年雄性大鼠的毒性评价：血液学方面。
Toxicity Evaluation of the Subacute Diazinon in Aged Male Rats: Hematological Aspects.
机构信息
Department of Basic Medical Sciences, Neyshabur University of Medical Sciences, Neyshabur, Iran
Medical Toxicology and Drug Abuse Research Center (MTDRC), Birjand University of Medical Sciences (BUMS), Birjand, Iran
出版信息
Cardiovasc Hematol Disord Drug Targets. 2020;20(3):198-201. doi: 10.2174/1871529X20666200305103007.
BACKGROUND & OBJECTIVE: Age-dependent Organophosphates (OPs) toxicity is a controversial topic. The present study was designed to investigate the effect of the sub-acute exposure to diazinon (DZN), one of the main OPs insecticides, on the hematological alterations in adult and aged male rats.
METHODS
For the aim of this approach, the adult and aged rats were administered with DZN (15 mg/kg, orally) for 4 weeks. Then, the blood samples were collected from the retro-orbital sinus for measuring red blood cell (RBC), hemoglobin (Hb), hematocrit (Hct), platelets (PLT), MCV (mean corpuscular volume), mean corpuscular hemoglobin (MCH), and mean corpuscular hemoglobin (MCHC).
RESULTS
The obtained results indicated that DZN significantly decreased RBCs (4.93 ± 0.41), Htc (28.12 ± 1.21), Hb (10.31 ± 0.36), MCHC (30.51 ± 2.04), MCV (62.86 ± 2.58), and PLT (265.6 ± 34.81) values in the adult and aged rats versus the age-matched control rats. Moreover, RBC, Hb, and Htc levels decreased significantly in the aged rats versus adult rats. However, no significant differences were observed between MCHC, MCV, and PLT levels in adult and aged rats. Moreover, the MCH concentration did not change in any group. Additionally, DZN did not deteriorate the hematological alterations in the aged rats versus adult rats.
CONCLUSION
the present study showed that the toxicity of DZN is not associated with age. However, more studies should be conducted to confirm this finding.
背景与目的
年龄相关的有机磷化合物（OPs）毒性是一个有争议的话题。本研究旨在研究亚急性暴露于二嗪农（DZN）（一种主要的有机磷杀虫剂）对成年和老年雄性大鼠血液学改变的影响。
方法
为了达到这个目的，成年和老年大鼠分别用 DZN（15mg/kg，口服）处理 4 周。然后，从眼眶后窦采集血液样本，用于测量红细胞（RBC）、血红蛋白（Hb）、血细胞比容（Hct）、血小板（PLT）、平均红细胞体积（MCV）、平均红细胞血红蛋白（MCH）和平均红细胞血红蛋白浓度（MCHC）。
结果
结果表明，DZN 显著降低了成年和老年大鼠的 RBC（4.93±0.41）、Htc（28.12±1.21）、Hb（10.31±0.36）、MCHC（30.51±2.04）、MCV（62.86±2.58）和 PLT（265.6±34.81）值，与年龄匹配的对照组大鼠相比。此外，与成年大鼠相比，老年大鼠的 RBC、Hb 和 Htc 水平显著降低。然而，成年和老年大鼠的 MCHC、MCV 和 PLT 水平没有显著差异。此外，MCH 浓度在任何组都没有变化。此外，DZN 并没有使老年大鼠的血液学改变恶化。
结论
本研究表明，DZN 的毒性与年龄无关。然而，还需要更多的研究来证实这一发现。
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