Santana V
Immunology. 1977 Feb;32(2):273-8.
Murine lymphoid cells from the thymus, lymph node and spleen were shown by indirect immunofluorescence, to bear membrane receptors for purified IgM of human origin. The bond between IgM and the cells took place through the Fc re gion, as demonstrated with isolated fragments of the normal IgM molecule. Two distinct myeloma IgM lacked this biological activity. The cytophilic origin of part of the immunoglobulin usually described on T-cell membranes is discussed.
通过间接免疫荧光法显示，来自小鼠胸腺、淋巴结和脾脏的淋巴细胞带有源自人类的纯化IgM的膜受体。如用正常IgM分子的分离片段所证实的，IgM与细胞之间的结合是通过Fc区域发生的。两种不同的骨髓瘤IgM缺乏这种生物学活性。本文讨论了通常描述于T细胞膜上的部分免疫球蛋白的嗜细胞性起源。
