Dal Monte Massimo, Cammalleri Maurizio, Pezzino Salvatore, Corsaro Roberta, Pescosolido Nicola, Bagnoli Paola, Rusciano Dario
Department of Biology, University of Pisa, via San Zeno, 31, 56127 Pisa, Italy.
Sooft Research Center, Viale Andrea Doria, 21, 95125 Catania, Italy.
Diagnostics (Basel). 2020 Mar 3;10(3):138. doi: 10.3390/diagnostics10030138.
Melatoninergic agents are known to reduce intraocular pressure (IOP). The present study was performed to evaluate the effect of nanomicellar formulations of melatoninergic agents on IOP in the rat.
Tonometry was used to measure IOP in eyes instilled with melatonin or agomelatine. Ocular hypertension was induced by the injection of methylcellulose in the anterior chamber.
Melatonin formulated in nanomicelles had a longer lasting hypotonizing effect on IOP with respect to melatonin in saline. Nanomicellar formulations of melatonin and agomelatine, either alone or in combination, had lowering effects that did not depend on their concentration or their combination, which, however, resulted in an increased duration of the hypotonizing effect. The duration of the lowering effect was further increased by the addition of lipoic acid.
We demonstrated the effective hypotonizing activity of melatonin and agomelatine in combination with lipoic acid. Although results in animals cannot be directly translated to humans, the possibility of developing novel therapeutical approaches for patients suffering from hypertensive glaucoma should be considered.
已知褪黑素能药物可降低眼压（IOP）。本研究旨在评估褪黑素能药物的纳米胶束制剂对大鼠眼压的影响。
使用眼压计测量滴入褪黑素或阿戈美拉汀的眼睛的眼压。通过在前房注射甲基纤维素诱导高眼压。
与盐水中的褪黑素相比，纳米胶束制剂的褪黑素对眼压具有更持久的降压作用。褪黑素和阿戈美拉汀的纳米胶束制剂单独或联合使用均具有降压作用，其降压作用不依赖于它们的浓度或联合使用情况，但联合使用会导致降压作用持续时间增加。添加硫辛酸可进一步延长降压作用的持续时间。
我们证明了褪黑素和阿戈美拉汀与硫辛酸联合使用具有有效的降压活性。尽管动物实验结果不能直接类推到人类，但应考虑为患有高血压性青光眼的患者开发新治疗方法的可能性。
