Nishioka Hiroshi, Hirano Asao, Asa Sylvia L
Bluestone Laboratory, Division of Neuropathology, Department of Pathology, Montefiore Medical Center, 111 East 210th Street, 10467, Bronx, NY.
Department of Pathology, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.
Endocr Pathol. 1992 Mar;3(1):47-51. doi: 10.1007/BF02921343.
A silent corticotroph adenoma with multiple cysts was found incidentally at autopsy. By immunohistochemistry, most of the adenoma cells contained reactivity for adrenocorticotropic hormone and beta-endorphin; a few cells stained for beta-subunit of luteinizing hormone. The cysts, interspersed within the tumor, were lined by cuboidal epithelium with foci of stratified squamous epithelium. The lining cells contained immunoreactive keratin; some cells were positive for S-100 protein or glial fibrillary acidic protein, and a few cells were also immuno-stained for adrenocorticotropic hormone and beta-endorphin. It is suggested that this tumor may represent a neoplasm of pars intermedia derivation.
尸检时偶然发现一例伴有多个囊肿的无功能性促肾上腺皮质激素腺瘤。免疫组织化学检测显示，大多数腺瘤细胞对促肾上腺皮质激素和β-内啡肽呈阳性反应；少数细胞对促黄体生成素β亚基呈阳性染色。囊肿散布于肿瘤内，内衬立方上皮，有局灶性复层鳞状上皮。内衬细胞含有免疫反应性角蛋白；一些细胞S-100蛋白或胶质纤维酸性蛋白呈阳性，少数细胞对促肾上腺皮质激素和β-内啡肽也呈免疫染色阳性。提示该肿瘤可能起源于中间部的肿瘤。
