Halmi N S, Peterson M E, Colurso G J, Liotta A S, Krieger D T
Science. 1981 Jan 2;211(4477):72-4. doi: 10.1126/science.6255564.
The pituitary intermediate lobe of most species is cytologically monotonous, but that of the dog is composed of two immunocytochemically distinct cell types. The predominant A cells are typical pars intermedia cells: they stain immunocytochemically for alpha-melanotropin and, more weakly, for adrenocorticotropin and beta-lipotropin. The B cells are like the corticotrophs of the anterior lobe: they stain intensely for adrenocorticotropin and beta-lipotropin but not for alpha-melanotropin. The B cells may account for the high concentration of bioactive adrenocorticotropin measured in the canine pars intermedia, and may explain why in dogs adenomas causing Cushing's disease through hypersecretion of adrenocorticotropin can arise from the intermediate as well as the anterior pituitary lobe.
大多数物种的垂体中间叶在细胞结构上较为单一，但犬类的垂体中间叶由两种免疫细胞化学性质不同的细胞类型组成。占主导地位的A细胞是典型的中间部细胞：它们对α-促黑素进行免疫细胞化学染色，对促肾上腺皮质激素和β-促脂素的染色较弱。B细胞类似于前叶的促肾上腺皮质激素细胞：它们对促肾上腺皮质激素和β-促脂素染色强烈，但对α-促黑素不染色。B细胞可能是犬类垂体中间部中生物活性促肾上腺皮质激素浓度高的原因，也可以解释为什么在犬类中，通过促肾上腺皮质激素分泌过多导致库欣病的腺瘤既可以起源于垂体前叶，也可以起源于垂体中间叶。
