Center for Medical Statistics, Informatics and Intelligent Systems, Section for Medical Statistics, Medical University Vienna, Austria.
Center for Medical Statistics, Informatics and Intelligent Systems, Section for Clinical Biometrics, Medical University Vienna, Austria.
Lab Anim. 2021 Feb;55(1):65-75. doi: 10.1177/0023677220907617. Epub 2020 Mar 5.
The recent discussion on the reproducibility of scientific results is particularly relevant for preclinical research with animal models. Within certain areas of preclinical research, there exists the tradition of repeating an experiment at least twice to demonstrate replicability. If the results of the first two experiments do not agree, then the experiment might be repeated a third time. Sometimes data of one representative experiment are shown; sometimes data from different experiments are pooled. However, there are hardly any guidelines about how to plan for such an experimental design or how to report the results obtained. This article provides a thorough statistical analysis of pre-planned experimental replications as they are currently often applied in practice and gives some recommendations about how to improve on study design and statistical analysis.
最近关于科学结果可重复性的讨论对于使用动物模型的临床前研究尤为相关。在临床前研究的某些领域，存在着重复实验至少两次以证明可重复性的传统。如果前两个实验的结果不一致，则可能会进行第三次实验。有时会显示一个代表性实验的数据；有时会合并来自不同实验的数据。但是，几乎没有关于如何规划这种实验设计或如何报告所获得结果的指南。本文对目前在实践中经常应用的预先计划的实验重复进行了全面的统计分析，并就如何改进研究设计和统计分析提出了一些建议。
