Department of Neurosurgery, University of Michigan, R5018 BSRB, 109 Zina Pitcher Place, Ann Arbor, MI, 48109-2200, USA.
Gagle Brook House, Chesterton, Bicester, OX26 1UF, UK.
Fluids Barriers CNS. 2020 Mar 5;17(1):20. doi: 10.1186/s12987-020-00181-9.
This editorial highlights advances in brain barrier and brain fluid research published in 2019, as well as addressing current controversies and pressing needs. Topics include recent advances related to: the cerebral endothelium and the neurovascular unit; the choroid plexus, arachnoid membrane; cerebrospinal fluid and the glymphatic hypothesis; the impact of disease states on brain barriers and brain fluids; drug delivery to the brain; and translation of preclinical data to the clinic. This editorial also mourns the loss of two important figures in the field, Malcolm B. Segal and Edward G. Stopa.
本社论重点介绍了 2019 年发表的关于脑屏障和脑液研究的进展，并探讨了当前的争议和迫切需求。主题包括与以下内容相关的最新进展：脑内皮细胞和神经血管单元；脉络丛、蛛网膜；脑脊液和胶状淋巴假说；疾病状态对脑屏障和脑液的影响；药物递送到大脑；以及临床前数据向临床的转化。本社论还对该领域两位重要人物马尔科姆·B·西格尔和爱德华·G·斯托帕的去世表示哀悼。
