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Children (Basel). 2022 Dec 12;9(12):1948. doi: 10.3390/children9121948.
2
IL-17/CXCL5 signaling within the oligovascular niche mediates human and mouse white matter injury.IL-17/CXCL5 信号在内寡血管龛中介导人类和小鼠的白质损伤。
Cell Rep. 2022 Dec 20;41(12):111848. doi: 10.1016/j.celrep.2022.111848.
3
Endothelial cells regulate astrocyte to neural progenitor cell trans-differentiation in a mouse model of stroke.内皮细胞在中风小鼠模型中调节星形胶质细胞向神经祖细胞的转分化。
Nat Commun. 2022 Dec 19;13(1):7812. doi: 10.1038/s41467-022-35498-6.
4
Brain autopsies of critically ill COVID-19 patients demonstrate heterogeneous profile of acute vascular injury, inflammation and age-linked chronic brain diseases.危重症 COVID-19 患者的大脑尸检显示出急性血管损伤、炎症和与年龄相关的慢性脑部疾病的异质表现。
Acta Neuropathol Commun. 2022 Dec 17;10(1):186. doi: 10.1186/s40478-022-01493-7.
5
Measurements of cerebrospinal fluid production: a review of the limitations and advantages of current methodologies.脑脊液生成的测量：对当前方法学的局限性和优势的综述。
Fluids Barriers CNS. 2022 Dec 15;19(1):101. doi: 10.1186/s12987-022-00382-4.
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Soluble TREM2 levels associate with conversion from mild cognitive impairment to Alzheimer's disease.可溶性 TREM2 水平与从轻度认知障碍到阿尔茨海默病的转化相关。
J Clin Invest. 2022 Dec 15;132(24):e158708. doi: 10.1172/JCI158708.
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8
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9
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年度回顾：2022 年的脑屏障和脑液研究。

A year in review: brain barriers and brain fluids research in 2022.

机构信息

Department of Neurosurgery, University of Michigan, R5018 BSRB 109 Zina Pitcher Place, Ann Arbor, MI, 48109-2200, USA.

, Bicester, OX26 1UF, UK.

出版信息

Fluids Barriers CNS. 2023 Apr 21;20(1):30. doi: 10.1186/s12987-023-00429-0.

DOI:10.1186/s12987-023-00429-0
PMID:37085841
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10120509/
Abstract

This aim of this editorial is to highlight progress made in brain barrier and brain fluid research in 2022. It covers studies on the blood-brain, blood-retina and blood-CSF barriers (choroid plexus and meninges), signaling within the neurovascular unit and elements of the brain fluid systems. It further discusses how brain barriers and brain fluid systems are impacted in CNS diseases, their role in disease progression and progress being made in treating such diseases.

摘要

本社论的目的是强调 2022 年在血脑屏障和脑液研究方面取得的进展。它涵盖了对血脑、血视网膜和血脑脊液（脉络丛和脑膜）屏障、神经血管单元内信号以及脑液系统成分的研究。它进一步讨论了中枢神经系统疾病如何影响血脑屏障和脑液系统，它们在疾病进展中的作用以及在治疗此类疾病方面取得的进展。