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2020 年的脑屏障和脑液研究,以及 CNS 液-屏障专题系列中关于血脑屏障和神经血管单元体外模型构建进展的研究。

Brain Barriers and brain fluids research in 2020 and the fluids and barriers of the CNS thematic series on advances in in vitro modeling of the blood-brain barrier and neurovascular unit.

机构信息

Department of Neurosurgery, University of Michigan, Ann Arbor, MI, 48105, USA.

Department of Neurosurgery, University of Michigan, 109 Zina Pitcher Place, Ann Arbor, R5018 BSRB, MI, 48109-2200, USA.

出版信息

Fluids Barriers CNS. 2021 May 21;18(1):24. doi: 10.1186/s12987-021-00258-z.

Abstract

This editorial discusses advances in brain barrier and brain fluid research in 2020. Topics include: the cerebral endothelium and the neurovascular unit; the choroid plexus; the meninges; cerebrospinal fluid and the glymphatic system; disease states impacting the brain barriers and brain fluids; drug delivery to the brain. This editorial also highlights the recently completed Fluids Barriers CNS thematic series entitled, 'Advances in in vitro modeling of the blood-brain barrier and neurovascular unit'. Such in vitro modeling is progressing rapidly.

摘要

本社论讨论了 2020 年在脑屏障和脑液研究方面的进展。主题包括:大脑内皮细胞和神经血管单元;脉络丛;脑膜;脑脊液和脑淋巴系统;影响脑屏障和脑液的疾病状态;药物递送到大脑。本社论还重点介绍了最近完成的题为“血脑屏障和神经血管单元体外模型研究进展”的《中枢神经系统液流屏障专题系列》。这种体外模型正在迅速发展。

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本文引用的文献

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Meningeal blood-brain barrier disruption in acute traumatic brain injury.急性创伤性脑损伤中的脑膜血脑屏障破坏
Brain Commun. 2020 Sep 9;2(2):fcaa143. doi: 10.1093/braincomms/fcaa143. eCollection 2020.
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Brain Commun. 2020 Nov 6;2(2):fcaa187. doi: 10.1093/braincomms/fcaa187. eCollection 2020.
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Single-Cell Analysis of Blood-Brain Barrier Response to Pericyte Loss.单细胞分析血脑屏障对周细胞缺失的反应。
Circ Res. 2021 Feb 19;128(4):e46-e62. doi: 10.1161/CIRCRESAHA.120.317473. Epub 2020 Dec 30.
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Attenuated CSF-1R signalling drives cerebrovascular pathology.减弱 CSF-1R 信号传递可导致脑血管病变。
EMBO Mol Med. 2021 Feb 5;13(2):e12889. doi: 10.15252/emmm.202012889. Epub 2020 Dec 22.

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