Division of Family Medicine and Primary Health Care, JC School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, China.
Sci Rep. 2020 Mar 5;10(1):4137. doi: 10.1038/s41598-020-60901-x.
The aim of our study was to identify the incidence rate of and the risk factors for mild cognitive impairment (MCI) among Chinese older adults with multimorbidity in primary care in Hong Kong. Older adults aged 60 years and above with multimorbidity were recruited from the public primary care clinics in Hong Kong. Incidence rates were calculated with the person-years. Cox proportional hazard regression models were used to predict the risk factors for MCI. Sensitivity analysis was performed using multiple imputation. Among 462 participants included in the main analysis, 45 progressed from normal to MCI with an incidence rate of 80.9 cases per 1000 person-years. Older age (HR 2.82, 95% CI 1.26-6.28) and being single (HR 2.15, 95% CI 1.11-4.19) were risk factors for developing MCI in the multivariable regression model. A total of 660 participants were included in the sensitivity analysis, with an MCI incidence of 114.4 cases per 1000 person-years. Older age and being single remained to be risk factors for MCI among older adults with multimorbidity. There may be a high incidence of MCI among Chinese older adults with multimorbidity in primary care in Hong Kong. Future larger studies need to confirm the prevalence and incidence of MCI among primary care Chinese patients.
我们的研究目的是确定香港基层医疗中老年多病患者轻度认知障碍（MCI）的发生率和危险因素。从香港的公立基层医疗诊所招募了年龄在 60 岁及以上且患有多种疾病的老年人。使用人年计算发病率。使用 Cox 比例风险回归模型预测 MCI 的危险因素。使用多重插补进行敏感性分析。在主要分析中纳入的 462 名参与者中，45 名从正常状态进展为 MCI，发病率为每 1000 人年 80.9 例。在多变量回归模型中，年龄较大（HR 2.82，95%CI 1.26-6.28）和单身（HR 2.15，95%CI 1.11-4.19）是发生 MCI 的危险因素。共有 660 名参与者纳入敏感性分析，MCI 的发病率为每 1000 人年 114.4 例。在患有多种疾病的老年人中，年龄较大和单身仍然是 MCI 的危险因素。香港基层医疗中老年多病患者中 MCI 的发病率可能较高。未来需要更大规模的研究来证实基层医疗中国患者 MCI 的患病率和发病率。
