Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China.
Lab of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, MD, USA.
J Alzheimers Dis. 2018;66(4):1453-1462. doi: 10.3233/JAD-180805.
Alzheimer's disease (AD) is the most common form of dementia, and mild cognitive impairment (MCI) is a transitional phase between healthy cognition and dementia. Physical activity (PA) has protective effects on cognitive decline. However, few studies have examined how PA and sedentary behavior is structured throughout the day in older adults across varied cognitive status in Hong Kong.
This study aimed to compare patterns of PA and sedentary behavior among individuals with AD, MCI, or normal cognition living in Hong Kong.
Participants in the MrOs and MsOs Hong Kong cohort study and the Hong Kong AD biomarker study (n = 810) wore a wrist-worn accelerometer for 7 days in free-living environment. Patterns of PA in wake time and in-bed time, and detailed analysis of sedentary bouts were compared between groups using analysis of covariance adjusting for covariates.
Participants with MCI and low MoCA only did not differ from their cognitively normal peers in PA and sedentary behavior. Nevertheless, when comparing to the others, participants with AD exhibited significantly lower average daily counts per minute during the day (p < 0.05), and tended to start their activity later in the morning. AD participants spent a larger proportion of time in sedentary behavior (p < 0.05) and had more sedentary bouts≥30 minutes (p < 0.05).
The pattern of PA and sedentary behavior was different between individuals with AD and the others. Cognitive status may alter the purpose and type of PA intervention for AD individuals.
阿尔茨海默病（AD）是最常见的痴呆类型，而轻度认知障碍（MCI）是健康认知与痴呆之间的过渡阶段。身体活动（PA）对认知能力下降具有保护作用。然而，在香港，很少有研究调查不同认知状态的老年人全天 PA 和久坐行为的结构如何。
本研究旨在比较 AD、MCI 和认知正常的香港老年人的 PA 和久坐行为模式。
MrOs 和 MsOs 香港队列研究和香港 AD 生物标志物研究（n=810）的参与者在自由生活环境中佩戴腕戴式加速度计 7 天。使用协方差分析调整协变量比较组间清醒时间和卧床时间的 PA 模式，以及久坐行为的详细分析。
仅 MCI 和低 MoCA 的参与者在 PA 和久坐行为方面与认知正常的同龄人没有差异。然而，与其他人相比，AD 参与者白天的平均每分钟计数明显较低（p<0.05），并且早晨活动开始较晚。AD 参与者久坐时间比例较高（p<0.05），并且有更多≥30 分钟的久坐行为（p<0.05）。
AD 患者和其他患者的 PA 和久坐行为模式不同。认知状态可能会改变 AD 患者的 PA 干预目的和类型。
