原发性二尖瓣反流病理生理学中左心房排空分数降低与糜酶激活

Reduced Left Atrial Emptying Fraction and Chymase Activation in Pathophysiology of Primary Mitral Regurgitation.

作者信息

Butts Brittany, Ahmed Mustafa I, Bajaj Navkaranbir S, Cox Powell Pamela, Pat Betty, Litovsky Silvio, Gupta Himanshu, Lloyd Steven G, Denney Thomas S, Zhang Xiaoxia, Aban Inmaculada, Sadayappan Sakthivel, McNamara James W, Watson Michael J, Ferrario Carlos M, Collawn James F, Lewis Clifton, Davies James E, Dell'Italia Louis J

机构信息

Department of Medicine, Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, Alabama.

Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama.

出版信息

JACC Basic Transl Sci. 2020 Jan 22;5(2):109-122. doi: 10.1016/j.jacbts.2019.11.006. eCollection 2020 Feb.

Increasing left atrial (LA) size predicts outcomes in patients with isolated mitral regurgitation (MR). Chymase is plentiful in the human heart and affects extracellular matrix remodeling. Chymase activation correlates to LA fibrosis, LA enlargement, and a decreased total LA emptying fraction in addition to having a potential intracellular role in mediating myofibrillar breakdown in LA myocytes. Because of the unreliability of the left ventricular ejection fraction in predicting outcomes in MR, LA size and the total LA emptying fraction may be more suitable indicators for timing of surgical intervention.