Department of Mechanical Engineering, Khalifa University of Science and Technology, Abu Dhabi 127788, UAE.
System on Chip Center, Khalifa University of Science and Technology, Abu Dhabi 127788, UAE.
Langmuir. 2020 Mar 31;36(12):3016-3028. doi: 10.1021/acs.langmuir.0c00187. Epub 2020 Mar 18.
The dissipative particle dynamics (DPD) technique was employed to design multiple microfluidic devices for investigating the motion of bioparticles at low Reynolds numbers. A DPD in-house FORTRAN code was developed to simulate the trajectories of two microparticles in the presence of hydrodynamic and transverse deflecting force fields via considering interparticle interaction forces. The particle-particle interactions were described by using a simplified version of the Morse potential. The transverse deflecting force considered in this microfluidic application was the dielectrophoresis (DEP) force. Multiple microfluidic devices with different configurations of microelectrodes were numerically designed to investigate the dielectrophoretic behavior of bioparticles for their trajectories and the focusing of bioparticles into a single stream in the middle of the microchannel. The DPD simulation results were verified and validated against previously reported numerical and experimental works in the literature. The computationally designed microdevices were fabricated by employing standard lithographic techniques, and experiments were conducted via taking red blood cells as the representative bioparticles. The experimental results for the trajectories and focusing showed good agreement with the numerical results.
耗散粒子动力学（DPD）技术被用于设计多个微流控装置，以研究低雷诺数下生物粒子的运动。开发了一个 DPD 内部 FORTRAN 代码，通过考虑粒子间相互作用力，模拟存在水动力和横向偏转力场时两个微粒子的轨迹。粒子-粒子相互作用通过使用 Morse 势的简化版本来描述。在这个微流控应用中考虑的横向偏转力是介电泳（DEP）力。设计了多个具有不同微电极配置的微流控装置，以研究生物粒子的介电泳行为，包括它们的轨迹和将生物粒子聚焦到微通道中间的单个流中。DPD 模拟结果与文献中以前报道的数值和实验工作进行了验证和验证。通过采用标准光刻技术制造了计算设计的微器件，并通过将红细胞作为代表性生物粒子进行了实验。轨迹和聚焦的实验结果与数值结果吻合良好。
