Department of Mechanical Engineering, Khalifa University of Science and Technology, 127788, Abu Dhabi, UAE.
Department of Aerospace Engineering, Khalifa University of Science and Technology, 127788, Abu Dhabi, UAE.
Biomech Model Mechanobiol. 2020 Feb;19(1):389-400. doi: 10.1007/s10237-019-01216-3. Epub 2019 Aug 31.
The dissipative particle dynamics (DPD) technique is employed to model the trajectories of micro-objects in a practical microfluidic device. The simulation approach is first developed using an in-house Fortran code to model Stokes flow at Reynolds number of 0.01. The extremely low Reynolds number is achieved by adjusting the DPD parameters, such as force coefficients, thermal energies of the particles, and time steps. After matching the numerical flow profile with the analytical results, the technique is developed further to simulate the deflection of micro-objects under the effect of a deflecting external force in a rectangular microchannel. A mapping algorithm is introduced to establish the scaling relationship for the deflecting force between the physical device and the DPD domain. Dielectrophoresis is studied as a case study for the deflecting force, and the trajectory of a single red blood cell under the influence of the dielectrophoretic force is simulated. The device is fabricated using standard microfabrication techniques, and the experiments involving a dilute sample of red blood cells are performed at two different cases of the actuation voltage. Good agreement between the numerical and experimental results is achieved.
耗散粒子动力学（DPD）技术被用于模拟实际微流控设备中微物体的轨迹。首先使用内部 Fortran 代码开发了模拟雷诺数为 0.01 的斯托克斯流的仿真方法。通过调整 DPD 参数（如力系数、粒子的热能和时间步长），实现了极低的雷诺数。在将数值流型与分析结果匹配后，进一步开发了该技术以模拟微通道中在外部偏转力作用下微物体的偏转。引入了映射算法以建立物理设备和 DPD 域之间的偏转力的比例关系。以电动力学为例研究了偏转力，模拟了单个红细胞在电动力学力作用下的轨迹。该设备采用标准微加工技术制造，并在两种不同的激励电压情况下对红细胞的稀样进行了实验。数值和实验结果之间取得了良好的一致性。
