State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.
Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, No. 14, 3rd Section, South Renmin Road, Chengdu, 610041, Sichuan, China.
Stem Cell Res Ther. 2020 Mar 6;11(1):109. doi: 10.1186/s13287-020-01625-7.
Bone diseases such as osteoarthritis, osteoporosis, and bone tumor present a severe public health problem. Osteogenic differentiation is a complex process associated with the differentiation of different cells, which could regulate transcription factors, cytokines, many signaling pathways, noncoding RNAs (ncRNAs), and epigenetic modulation. DNA methylation is a kind of stable epigenetic alterations in CpG islands without DNA sequence changes and is involved in cancer and other diseases, including bone development and homeostasis. ncRNAs can perform their crucial biological functions at the RNA level, and many findings have demonstrated essential functions of ncRNAs in osteogenic differentiation. In this review, we highlight current researches in DNA methylation of two relevant ncRNAs, including microRNAs and long noncoding RNAs, in the initiation and progression of osteogenesis and bone diseases.
骨骼疾病，如骨关节炎、骨质疏松症和骨肿瘤，构成了严重的公共健康问题。成骨分化是一个涉及不同细胞分化的复杂过程，它可以调节转录因子、细胞因子、许多信号通路、非编码 RNA（ncRNA）和表观遗传调控。DNA 甲基化是 CpG 岛中一种没有 DNA 序列变化的稳定表观遗传改变，与癌症和其他疾病有关，包括骨骼发育和稳态。ncRNA 可以在 RNA 水平上发挥其关键的生物学功能，许多研究结果表明 ncRNA 在成骨分化中的重要作用。在这篇综述中，我们强调了两个相关的 ncRNA（microRNA 和长非编码 RNA）在成骨作用和骨疾病发生中的 DNA 甲基化的最新研究进展。
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