耳硬化症患者中 GPER-1 和性激素水平。

GPER-1 and sex-hormone levels in patients with otosclerosis.

机构信息

Department of Otorhinolaryngology, Faculty of Medicine, Zonguldak Bülent Ecevit University, Zonguldak, Turkey.

出版信息

Am J Otolaryngol. 2020 May-Jun;41(3):102442. doi: 10.1016/j.amjoto.2020.102442. Epub 2020 Feb 24.

DOI:10.1016/j.amjoto.2020.102442

PMID:32144019

Abstract

OBJECTIVE

Otosclerosis is a widespread disease but the etiopathogenesis is still not fully understood. Hormonal factors especially estrogens are accused in recent years. The study aimed to evaluate the levels of G-protein associated membrane estrogen receptor-1 (GPER-1) and sex-hormones in patients with otosclerosis.

SUBJECT AND METHODS

The study included 60 people (30 otosclerosis patients, 30 control group). Serum sex-hormone (estradiol, progesterone, prolactin and total testosterone) and GPER-1 levels were measured in otosclerosis patients and compared with the normal population. For the otosclerosis group, air conduction and bone conduction thresholds and air-bone gaps were viewed from audiograms and the relationships between hearing and GPER-1 or sex-hormone levels were also investigated.

RESULTS

Sex-hormone levels were not different between the groups. GPER-1 level was significantly lower in the otosclerosis group [3.1353 (0.76-8.21) ng/mL] than the control group [5.4773 (0.96-20.31) ng/mL] (p =0.017). Differential diagnosis with ROC analysis for the GPER-1 level was also significant (p=0.017). GPER-1 level was significantly lower for the females than the males in the otosclerosis group (p=0.043). Serum estradiol, progesterone, and prolactin levels were significantly higher (p=0.02, p =0.029 and p=0.019 respectively) and the GPER-1 level was significantly lower (p= 0.04) in the female patients compared to the female controls. There was no statistically significant relationship between GPER-1 or sex-hormone levels and hearing parameters.

CONCLUSION

GPER-1 level was lower in the otosclerosis patients compared to healthy volunteers and also lower in females than males in the patient group. Female sex-hormone levels were higher and GPER-1 level was lower in the female patient group than the female control group. Neither GPER-1 nor sex-hormone levels were not predictive of hearing levels. These findings indicate that sex-hormones especially estrogen and GPER-1 might have a potential role in the etiopathogenesis of otosclerosis. This is the first study in the literature that investigates the GPER-1 values in otosclerosis.

摘要

目的

耳硬化症是一种广泛存在的疾病，但发病机制仍不完全清楚。近年来，人们指责激素因素，尤其是雌激素。本研究旨在评估耳硬化症患者中 G 蛋白偶联膜雌激素受体-1（GPER-1）和性激素的水平。

受试者和方法

本研究纳入 60 人（30 例耳硬化症患者，30 例对照组）。测量耳硬化症患者和正常人群的血清性激素（雌二醇、孕酮、催乳素和总睾酮）和 GPER-1 水平。对于耳硬化症组，从听力图中观察气导和骨导阈值以及气骨间隙，并研究听力与 GPER-1 或性激素水平之间的关系。

结果

两组间的性激素水平无差异。耳硬化症组的 GPER-1 水平[3.1353（0.76-8.21）ng/ml]明显低于对照组[5.4773（0.96-20.31）ng/ml]（p=0.017）。ROC 分析对 GPER-1 水平的诊断差异也有统计学意义（p=0.017）。耳硬化症组女性的 GPER-1 水平明显低于男性（p=0.043）。与女性对照组相比，女性患者的血清雌二醇、孕酮和催乳素水平明显升高（p=0.02、p=0.029 和 p=0.019），而 GPER-1 水平明显降低（p=0.04）。GPER-1 或性激素水平与听力参数之间无统计学显著关系。

结论

与健康志愿者相比，耳硬化症患者的 GPER-1 水平较低，且在患者组中女性的 GPER-1 水平也低于男性。与女性对照组相比，女性患者组的性激素水平较高，GPER-1 水平较低。GPER-1 或性激素水平均不能预测听力水平。这些发现表明，性激素，特别是雌激素和 GPER-1，可能在耳硬化症的发病机制中发挥作用。这是文献中首次研究耳硬化症中 GPER-1 的价值。