Department of Otorhinolaryngology, Faculty of Medicine, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey.
, Haydar Bey Mah. Sok. Beytepe sitesi 4. Blok No:13, 32120, Kahramanmaras, Turkey.
Eur Arch Otorhinolaryngol. 2018 Feb;275(2):469-476. doi: 10.1007/s00405-017-4862-7. Epub 2018 Jan 3.
Stuttering is a widespread but little understood disease. There has been a recent increase in neuropathophysiological, genetic, and biochemical studies related to the etiopathogenesis. As developmental stuttering continues in adult males, hormonal factors are thought to have an effect. In this study, an evaluation was made for the first time of serum GPER-1 level in patients with a stutter.
Prospective case control.
The study included 30 patients with a stutter, aged < 18 years, and 35 age-matched children as the control group. The Stuttering Severity Instrument-3 form was administered to the patients. Evaluations were made of serum GPER-1, TSH, estradiol, prolactin, and progesterone and testosterone levels.
GPER-1 level was determined as 0.51 (0.42-0.67) ng/mL in the patients and as 0.19 (0.13-0.25) ng/mL in the control group, and the difference was statistically significant (p < 0.001). A statistically significant difference was determined between genders with GPER-1 level of 0.56 (0.44-0.68) ng/mL in the male stuttering patient group and 0.44 (0.35-0.49) ng/mL in the female patient group (p = 0.026). Differential diagnosis with ROC analysis for the serum GPER-1 levels was statistically significant [Area under the ROC curve (AUC): 0.998, confidence interval, CI 0.992-1.000, p < 0.001].
The GPER-1 levels of the stuttering patients were found to be higher than those of the control group and GPER-1 levels of male patients were higher than those of females. As GPER-1 has high sensitivity and sensitivity, it could be considered important in the diagnosis and treatment of stuttering.
口吃是一种广泛存在但知之甚少的疾病。最近，与发病机制相关的神经病理生理学、遗传学和生物化学研究有所增加。由于口吃在成年男性中持续存在，人们认为激素因素有影响。在这项研究中，我们首次评估了口吃患者的血清 GPER-1 水平。
前瞻性病例对照。
该研究纳入了 30 名年龄<18 岁的口吃患者和 35 名年龄匹配的儿童作为对照组。对患者进行了口吃严重程度量表 3 型的评估。对血清 GPER-1、TSH、雌二醇、催乳素、孕酮和睾酮水平进行了评估。
患者组 GPER-1 水平为 0.51（0.42-0.67）ng/mL，对照组为 0.19（0.13-0.25）ng/mL，差异有统计学意义（p<0.001）。GPER-1 水平在男性和女性之间存在统计学差异，男性口吃患者组为 0.56（0.44-0.68）ng/mL，女性患者组为 0.44（0.35-0.49）ng/mL（p=0.026）。ROC 分析显示，血清 GPER-1 水平的鉴别诊断具有统计学意义[ROC 曲线下面积（AUC）：0.998，置信区间，CI 0.992-1.000，p<0.001]。
口吃患者的 GPER-1 水平高于对照组，男性患者的 GPER-1 水平高于女性。由于 GPER-1 具有较高的灵敏度和特异性，因此在口吃的诊断和治疗中可能具有重要意义。
