Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China.
Department of Endocrinology and Metabolism, Shanghai Zhongshan Hospital and Fudan Institute for Metabolic Diseases, Fudan University, Shanghai, China.
Diabetes Care. 2020 May;43(5):1008-1015. doi: 10.2337/dc19-1807. Epub 2020 Mar 6.
We aimed to evaluate trends in bone mineral density (BMD) and the prevalence of osteoporosis/osteopenia in U.S. adults with prediabetes and normal glucose regulation (NGR) and further investigate the association among prediabetes, osteopenia/osteoporosis, and fracture.
We collected and analyzed data from the U.S. National Health and Nutrition Examination Surveys during the period from 2005 to 2014. Femoral neck and lumbar spine BMD data were available for 5,310 adults with prediabetes and 5,162 adults with NGR >40 years old.
A shift was observed toward a lower BMD and a higher prevalence of osteopenia/osteoporosis at the femoral neck and lumbar spine in U.S. adults >40 years old with prediabetes since 2005, especially in men <60 and women ≥60 years old. A shift toward a higher prevalence of osteopenia/osteoporosis at the femoral neck was also observed in adults >40 years old with NGR. Moreover, prediabetes was associated with a higher prevalence of hip fracture, although participants with prediabetes had higher BMD and a lower prevalence of osteopenia/osteoporosis at the femoral neck.
There was a declining trend in BMD from 2005 to 2014 in U.S. adults >40 years old with prediabetes and NGR, and this trend was more significant in men <60 years old. Populations with prediabetes may be exposed to relatively higher BMD but a higher prevalence of fracture.
我们旨在评估美国患有前驱糖尿病和正常血糖调节（NGR）的成年人的骨密度（BMD）趋势和骨质疏松/骨量减少的患病率，并进一步探讨前驱糖尿病、骨量减少/骨质疏松症与骨折之间的关联。
我们收集并分析了 2005 年至 2014 年美国国家健康和营养调查的数据。共有 5310 名年龄大于 40 岁的前驱糖尿病患者和 5162 名 NGR 大于 40 岁的患者可提供股骨颈和腰椎 BMD 数据。
自 2005 年以来，美国年龄大于 40 岁的前驱糖尿病患者中，BMD 呈下降趋势，股骨颈和腰椎的骨质疏松/骨量减少的患病率更高，尤其是男性<60 岁和女性≥60 岁的患者。年龄大于 40 岁的 NGR 患者的股骨颈骨质疏松/骨量减少的患病率也呈上升趋势。此外，前驱糖尿病与髋部骨折的患病率更高相关，尽管前驱糖尿病患者的股骨颈 BMD 更高，骨质疏松/骨量减少的患病率更低。
自 2005 年至 2014 年，美国年龄大于 40 岁的前驱糖尿病和 NGR 成年人的 BMD 呈下降趋势，男性<60 岁的患者的下降趋势更为明显。前驱糖尿病患者的人群可能会面临相对较高的 BMD，但骨折的患病率较高。
